Pringuey D, Darcourt G
Clinique de Psychiatrie et de Psychologie Médicale, Centre Hospitalier Régional et Universitaire, Hôpital Pasteur, Nice.
Presse Med. 1990 Nov 28;19(40):1843-9.
Insomnia is a cardinal symptom of depression, side by side with alterations of mood and slowing down of psychomotor activities. It bears witness to a rupture in the built-in circadian rhythm: architectural changes in sleep betray a biological desynchronization. Insomnia is also a failed attempt at finding a solution to depression. Total deprivation of sleep for one night may damp down the depressive disorders, and so does partial sleep deprivation in the second part of the night during several days. This leads to the conclusion that the waking-sleep system participates in the expression of symptoms of depression or even contributes to the genesis of the disease.
失眠是抑郁症的主要症状之一，与情绪改变和精神运动活动减缓并存。它证明了内在昼夜节律的紊乱：睡眠结构的变化表明生物节律失调。失眠也是试图解决抑郁症但未成功的表现。一夜完全剥夺睡眠可能会减轻抑郁症状，连续数天在夜间后半段进行部分睡眠剥夺也有同样效果。由此得出结论，清醒 - 睡眠系统参与了抑郁症症状的表现，甚至对该疾病的发生也有促成作用。
