通过铜（I）催化（E）-2-乙炔基苯基查尔酮、磺酰叠氮化物和胺的反应，实现 1,2-二氢异喹啉-3(4H)-亚胺的多样性导向合成。

Diversity-oriented approach to 1,2-dihydroisoquinolin-3(4H)-imines via copper(I)-catalyzed reaction of (E)-2-ethynylphenylchalcone, sulfonyl azide and amine.

机构信息

Key Laboratory of Functional Small Organic Molecules, Ministry of Education and College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, China.

出版信息

Chem Commun (Camb). 2011 May 21;47(19):5623-5. doi: 10.1039/c1cc11176k. Epub 2011 Apr 11.

DOI:10.1039/c1cc11176k

PMID:21483921

Abstract

A three-component reaction of (E)-2-ethynylphenylchalcone, sulfonyl azide, and amine catalyzed by copper(I) chloride (5 mol%), in the presence of triethylamine, under mild conditions is described. This transformation proceeds efficiently to generate 1,2-dihydroisoquinolin-3(4H)-imines in good to excellent yields.

摘要

(E)-2-乙炔基苯并[C]色烯、磺酰叠氮化物和胺在五摩尔%的氯化亚铜、三乙胺存在下，于温和条件下发生三组分反应，有效地转化为 1,2-二氢异喹啉-3(4H)-亚胺，产率良好至优秀。