Department of Orthopaedic Surgery, Erstwhile KG Medical College, CSM Medical University, Lucknow, India.
Clinics (Sao Paulo). 2011;66(2):275-9. doi: 10.1590/s1807-59322011000200016.
Body mass index (BMI) and knee osteoarthritis have a strong association, but other anthropometric measures lack such associations. To date, no study has evaluated non-obese knee osteoarthritis to negate the systemic and metabolic effects of obesity. This study examines the validity of the contention that BMI and other anthropometric measures have a significant relationship with knee osteoarthritis.
In total, 180 subjects with a diagnosis of knee osteoarthritis were recruited and classified according to Kellgren-Lawrence (KL) grades. Body mass index, mid-upper arm circumference, waist-hip ratio and triceps-skinfold thickness were recorded by standard procedures. Osteoarthritis outcome scores (WOMAC) were evaluated.
(1) In both genders, the BMI was significantly higher for KL grade 4 than for grade 2; triceps-skinfold thickness was positively correlated with the joint space width of the tibial medial compartment. (2) In males, triceps-skinfold thickness significantly increased as the KL grades moved from 2 to 4; the significantly higher BMI found in varus aligned knees was positively correlated with WOMAC scores. (3) In females, the waist-hip ratio was significantly higher for KL grade 4 than for grade 2; a significant correlation was found between BMI and WOMAC scores. The waist-hip ratio was significantly associated with varus aligned knees and it positively correlated with WOMAC scores and with the joint space width of the tibial medial compartment. The mid-upper arm circumference demonstrated no correlation with knee osteoarthritis. CONCLUS'ON: This study validates the contention that BMI and other anthropometric measures have a significant association with knee osteoarthritis. Contrary to common belief, the triceps-skinfold thickness (peripheral fat) in males and the waist-hip ratio (central fat) in females were more strongly associated with knee osteoarthritis than BMI.
体重指数（BMI）与膝骨关节炎有很强的相关性，但其他人体测量指标则缺乏这种相关性。迄今为止，尚无研究评估过非肥胖性膝骨关节炎，以否定肥胖的全身和代谢影响。本研究旨在验证 BMI 和其他人体测量指标与膝骨关节炎显著相关的观点。
共招募了 180 名经诊断患有膝骨关节炎的患者，并根据 Kellgren-Lawrence（KL）分级进行分类。通过标准程序记录 BMI、中上臂围、腰臀比和三头肌皮褶厚度。评估骨关节炎结局评分（WOMAC）。
（1）在男女两性中，KL 分级 4 的 BMI 显著高于 KL 分级 2；三头肌皮褶厚度与胫骨内侧间室的关节间隙宽度呈正相关。（2）在男性中，随着 KL 分级从 2 级到 4 级，三头肌皮褶厚度显著增加；在内翻对齐的膝关节中，BMI 显著升高，与 WOMAC 评分呈正相关。（3）在女性中，KL 分级 4 的腰臀比显著高于 KL 分级 2；BMI 与 WOMAC 评分之间存在显著相关性。腰臀比与内翻对齐的膝关节显著相关，与 WOMAC 评分和胫骨内侧间室的关节间隙宽度呈正相关。中上臂围与膝骨关节炎无相关性。
本研究验证了 BMI 和其他人体测量指标与膝骨关节炎显著相关的观点。与普遍看法相反，男性的三头肌皮褶厚度（外周脂肪）和女性的腰臀比（中心脂肪）与膝骨关节炎的相关性强于 BMI。
