Department of Biology, Faculty of Sciences, University of Isfahan, Hezar-Jarib, Isfahan, Iran.
Med Oncol. 2012 Jun;29(2):516-20. doi: 10.1007/s12032-011-9936-6. Epub 2011 Apr 12.
To evaluate the association between breast cancer and cytosine-adenine (CA) dinucleotide repeat length polymorphisms in the promoter region of the Insulin-like Growth Factor 1 (IGF-1) gene, a case-control study of 215 breast cancer patients and 224 controls was conducted in Iranian women. The most common allele and genotype in both controls and patients were an allele length of 19 and a homozygous genotype of (CA)(19)/(CA)(19). Women with two alleles longer than 19 were found to be at a higher risk of breast cancer with an odds ratio of 4.1 (P = 0.0002). In contrast, women with two alleles shorter than 20 were at lower risk of breast cancer. These results suggest a novel association between CA repeat length in IGF-1 and risk of breast cancer.
为了评估胰岛素样生长因子 1（IGF-1）基因启动子区胞嘧啶-腺嘌呤（CA）二核苷酸重复长度多态性与乳腺癌之间的关系，在伊朗女性中进行了一项 215 例乳腺癌患者和 224 例对照的病例对照研究。在对照组和患者组中最常见的等位基因和基因型均为 19 个重复的等位基因长度和（CA）（19）/（CA）（19）纯合基因型。发现两个等位基因长度大于 19 的女性患乳腺癌的风险更高，比值比为 4.1（P = 0.0002）。相比之下，两个等位基因长度小于 20 的女性患乳腺癌的风险较低。这些结果表明 IGF-1 中的 CA 重复长度与乳腺癌风险之间存在新的关联。
