Topal Aşkın Ender, Eren Mehmet Nesimi
Cardiovascular Surgery Department, Dicle University Medicine Faculty, Diyarbakır 21280, Turkey.
Gen Thorac Cardiovasc Surg. 2011 Apr;59(4):254-60. doi: 10.1007/s11748-010-0721-9. Epub 2011 Apr 12.
Postoperative atrial fibrillation (AF) is the most common complication after coronary artery bypass graft (CABG) surgery, with an incidence of 20%-50%. The objective of this study was to investigate perioperative risk factors of postoperative sustained AF by the way of logistic regression analysis.
Data for the last 98 patients who had undergone CABG surgery before January 2010 were retrospectively collected and analyzed.
Postoperative sustained AF was detected in 34 (34.7%) patients. Mean arterial blood pressure, previous hypertension (HT), previous AF, previous chronic obstructive pulmonary disease, aortic cross-clamp time, cardiopulmonary bypass time, postoperative urea, postoperative creatinine, postoperative potassium, extubation time, chest tube drainage, units of transfused packed red blood cells (pRBC), and postoperative pneumonia were associated with higher occurrence of postoperative sustained AF according to the univariate analysis. Upon logistic regression analysis, pRBC transfusion, previous AF, and preoperative HT remained independent predictors for the development of postoperative sustained AF.
On-pump versus off-pump CABG is not significantly associated with AF development so long as the operating time does not extend over a certain time period. pRBC transfusion was the single risk factor that is amenable to intervention at the time of operation. Unneeded transfusion of pRBCs must be prohibited. Also, serious precautions must be taken against postoperative pneumonia to avoid postoperative AF occurrence.
术后房颤是冠状动脉旁路移植术(CABG)后最常见的并发症,发生率为20%-50%。本研究的目的是通过逻辑回归分析方法探讨术后持续性房颤的围手术期危险因素。
回顾性收集并分析2010年1月前接受CABG手术的98例患者的数据。
34例(34.7%)患者检测到术后持续性房颤。单因素分析显示,平均动脉血压、既往高血压(HT)、既往房颤、既往慢性阻塞性肺疾病、主动脉阻断时间、体外循环时间、术后尿素、术后肌酐、术后钾、拔管时间、胸管引流量、输注浓缩红细胞(pRBC)单位数及术后肺炎与术后持续性房颤的较高发生率相关。经逻辑回归分析,pRBC输血、既往房颤及术前HT仍是术后持续性房颤发生的独立预测因素。
只要手术时间不超过一定时间段,不停跳与停跳CABG与房颤发生无显著相关性。pRBC输血是手术时可进行干预的单一危险因素。必须禁止不必要的pRBC输血。此外,必须认真预防术后肺炎以避免术后房颤的发生。