Kosar K
Department of Pharmacological Propaedeutics, Faculty of Pharmacy, Charles University, Hradec Králové, Czechoslovakia.
Anat Anz. 1990;171(3):211-7.
The effects of a natural hormone hydrocortisone and of the synthetic corticoids dexamethasone and triamcinolone on several morphogenetic systems were investigated in 2, 3, 4 and 5 day-old chick embryos. Embryotoxic doses of the glucocorticoids were administered subgerminally on day 2, and intraamniotically on days 3, 4 and 5 of incubation. On the basis of morphological analysis of embryos performed on day 8 the malformation spectrum was determined, which shows nearly identical characteristics in all the corticoids under study. Morphogenetic systems of the body wall and face were affected most frequently; the eye only to a little extent, and the brain only rarely. No malformations of the limbs, trunk and heart were found. Embryolethal effect was observed approximately in a quarter of embryos of the individual experimental groups.
在2、3、4和5日龄的鸡胚中，研究了天然激素氢化可的松以及合成皮质类固醇地塞米松和曲安西龙对几种形态发生系统的影响。在孵化第2天，将胚胎毒性剂量的糖皮质激素经胚下给药，在孵化第3、4和5天经羊膜内给药。根据第8天对胚胎进行的形态学分析确定了畸形谱，在所研究的所有皮质类固醇中显示出几乎相同的特征。体壁和面部的形态发生系统受影响最频繁；眼睛仅受到轻微影响，而大脑仅很少受到影响。未发现四肢、躯干和心脏的畸形。在各个实验组中，约四分之一的胚胎观察到胚胎致死效应。
