First Surgical Oncology and General Surgery Department, Wielkopolska Cancer Center, Poznan, Poland.
Cancer. 2011 Nov 1;117(21):4812-22. doi: 10.1002/cncr.26087. Epub 2011 Apr 11.
Ever since Kitai first performed fluorescent navigation of sentinel lymph nodes (SLNs) using indocyanine green (ICG) dye with a charge-couple device and light emitting diodes, the intraoperative use of near infrared fluorescence has served a critical role in increasing our understanding in various fields of surgical oncology. Here the authors review the emerging role of the ICG fluorophore in the development of our comprehension of the lymphatic system and its use in SLN mapping and biopsy in various cancers. In addition, they introduce the novel role of ICG-guided video angiography as a new intraoperative method of assessing microvascular circulation. The authors attempt to discuss the promising potential in addition to assessing several challenges and limitations in the context of specific surgical procedures and ICG as a whole. PubMed and Medline literature databases were searched for ICG use in clinical surgical settings. Despite ICG's significant impact in various fields of surgical oncology, ICG is still in its nascent stages, and more in-depth studies need to be carried out to fully evaluate its potential and limitations.
自从 Kitai 首次使用电荷耦合器件和发光二极管的吲哚菁绿 (ICG) 染料进行前哨淋巴结 (SLN) 的荧光导航以来，近红外荧光在术中的应用在提高我们对各种外科肿瘤学领域的认识方面发挥了关键作用。在这里，作者回顾了 ICG 荧光团在我们对淋巴系统的理解以及在各种癌症的 SLN 绘图和活检中的应用方面的新兴作用。此外，他们还介绍了 ICG 引导的视频血管造影作为一种新的术中评估微血管循环的方法的新作用。作者试图在评估特定手术程序和 ICG 整体的几个挑战和局限性的背景下，讨论其有前途的潜力。作者在临床外科环境中对 ICG 的使用进行了 PubMed 和 Medline 文献数据库搜索。尽管 ICG 在各种外科肿瘤学领域产生了重大影响，但它仍处于起步阶段，需要进行更深入的研究，以充分评估其潜力和局限性。
