Jin Lu, He Li-ren, Fu De-yu
Department of Cardiovascular Diseases, Yueyang Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Mar;31(3):315-8.
To observe changes of soluble CD40 ligand (sCD40L) in patients with hyperlipidemia of blood stasis syndrome and its correlation with blood stasis syndrome integral, P-selectin, and high sensitive creatine reactive protein (hs-CRP), to investigate the roles of platelet activation and inflammation in the physiopathologic process of blood-stasis type hyperlipidemia, and to explore the pathogenetic mechanism of blood-stasis syndrome (BSS).
Seventy hyperlipidemia patients were assigned to two groups, 39 in the BSS group and 31 in the non-BSS group. Meanwhile, thirty healthy subjects were grouped as the control. Main physiochemical indices, blood levels of sCD40L, P-selectin, hs-CRP were detected in all. The correlations of the aforesaid indices were analyzed.
BSS score in the BSS group was higher than that in the non-BSS group and in the control group. Higher blood levels of P-selectin and sCD40L were shown in the BSS group than in the non-BSS group [(25.13 +/- 5.49) ng/L vs. (21.37 +/- 3.56) ng/L and (2.45 +/- 0.48) ng/L vs. (2.07 +/- 0. 41) ng/L] respectively, and the two indices were higher in hyperlipidemia patients than in healthy persons [(14.91 +/- 2.48) ng/L and (1.63 +/- 0.25) ng/L, P < 0.01]. Correlation analysis showed that in patients with hyperlipidemia, blood level of sCD40L was positively correlated with low-density lipoprotein cholesterol (LDL-C) level (r = 0.503, P < 0.01), P-selectin (r = 0.897, P < 0.01), and the BSS score (r = 0.603, P < 0.01).
The over-expressed sCD40L indicated persistent inflammatory state in patients with hyperlipidemia of BSS. BSS would further accelerate the chronic inflammation process of hyperlipidemia.
观察血瘀证高脂血症患者可溶性CD40配体（sCD40L）的变化及其与血瘀证积分、P-选择素和高敏肌酸反应蛋白（hs-CRP）的相关性，探讨血小板活化和炎症在血瘀型高脂血症病理生理过程中的作用，以及血瘀证的发病机制。
将70例高脂血症患者分为两组，血瘀证组39例，非血瘀证组31例。同时，将30例健康受试者作为对照组。检测所有对象的主要理化指标、sCD40L、P-选择素、hs-CRP的血药浓度。分析上述指标的相关性。
血瘀证组血瘀证积分高于非血瘀证组和对照组。血瘀证组P-选择素和sCD40L的血药浓度均高于非血瘀证组[分别为（25.13±5.49）ng/L对（21.37±3.56）ng/L和（2.45±0.48）ng/L对（2.07±0.41）ng/L]，且高脂血症患者这两项指标均高于健康人[（14.91±2.48）ng/L和（1.63±0.25）ng/L，P<0.01]。相关性分析显示，高脂血症患者sCD40L血药浓度与低密度脂蛋白胆固醇（LDL-C）水平呈正相关（r=0.503，P<0.01），与P-选择素呈正相关（r=0.897，P<0.01），与血瘀证积分呈正相关（r=0.603，P<0.01）。
sCD40L过表达提示血瘀证高脂血症患者存在持续炎症状态。血瘀证会进一步加速高脂血症的慢性炎症进程。
