Department of Internal Medicine, Gulhane School of Medicine, Ankara, Turkey.
Clin Biochem. 2012 Jan;45(1-2):92-5. doi: 10.1016/j.clinbiochem.2011.10.022. Epub 2011 Nov 7.
The data regarding circulating levels of markers of platelet activation and endothelial function in people with prediabetes are scant. The aim of the present study was to search blood levels of soluble CD40 ligand (sCD40L), soluble P-selectin (sP-sel) and von Willebrand Factor (vWF) in subjects with prediabetes, along with the effects of the metabolic syndrome (MetS) on these markers.
A total of 77 prediabetic individuals and 81 age, sex and body mass index matched healthy subjects with normal glucose tolerance (NGT) were prospectively analyzed. Anthropometric parameters, fasting plasma glucose, blood d lipid profiles and insulin resistance indexes were determined. Plasma sCD40L, sP-sel and vWF levels were measured by ELISA.
sCD40L, sP-sel and vWF levels in the prediabetic group were similar to those in the controls. However, prediabetic subjects with the MetS had significantly higher level of sCD40L compared to those without MetS. Moreover, sCD40L level correlated significantly with waist circumference, systolic blood pressure and HDL-cholesterol level in the patient group.
These data imply that MetS may contribute, at least in part, to the mechanism of platelet activation and endothelial dysfunction in people with prediabetes.
关于糖尿病前期患者血小板活化和内皮功能的循环标志物水平的数据很少。本研究旨在探讨糖尿病前期患者可溶性 CD40 配体 (sCD40L)、可溶性 P 选择素 (sP-sel) 和血管性血友病因子 (vWF) 的血液水平，并研究代谢综合征 (MetS) 对这些标志物的影响。
前瞻性分析了 77 例糖尿病前期患者和 81 例年龄、性别和体重指数匹配的糖耐量正常 (NGT) 健康对照者。测定了人体测量参数、空腹血糖、血脂谱和胰岛素抵抗指数。采用 ELISA 法测定血浆 sCD40L、sP-sel 和 vWF 水平。
糖尿病前期组的 sCD40L、sP-sel 和 vWF 水平与对照组相似。然而，患有 MetS 的糖尿病前期患者的 sCD40L 水平明显高于无 MetS 的患者。此外，sCD40L 水平与患者组的腰围、收缩压和 HDL-胆固醇水平呈显著相关。
这些数据表明，MetS 可能至少部分地促成了糖尿病前期患者血小板活化和内皮功能障碍的机制。
