Li Xiao-bin, Lan Xiao-yu, Ou Ai-hua
Department of Gynecology, Guangdong Provincial Chinese Medical Hospital, Guangzhou.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Mar;31(3):323-6.
To study the distribution laws of the Chinese medicine syndrome patterns and its correlated symptoms in patients with polycystic ovarian syndrome (PCOS), and the possible correlation between Chinese medicine syndrome patterns and PCOS associated parameters, thus to provide a guidance for selecting proper indices in curative effectiveness assessment.
Using clinical epidemiological methods and mathematical statistics, the Chinese medicine syndrome patterns were studied in 228 PCOS patients. The distribution features of Chinese medicine syndrome patterns were summarized.
Shen-deficiency blood-stasis syndrome was the most frequently seen in PCOS patients, followed by Pi-deficiency phlegm-dampness syndrome, Pi-Shen yang-deficiency syndrome, and Shen-yin deficiency syndrome. Positive correlation existed between serum levels of follicle stimulating hormone (FSH) and Pi-Shen yang-deficiency syndrome. Positive correlation existed between fasting blood sugar (FBS), waist to hip ratio (WHR), body mass index (BMI), fasting insulin (FIN), and Hirsutism score and Pi-deficiency phlegm-dampness syndrome. Positive correlation existed between serum levels of prolactin (PRL), estradiol (E2 ) and qi stagnancy and blood stasis syndrome. Positive correlation existed between serum progesterone (PRG) level, FSH, FIN, BMI, acne score and Gan stagnancy and blood heat syndrome. Positive correlation existed between luteinizing hormone (LH) and Shen-deficiency blood-stasis syndrome. Besides, LH/FSH >3 was possibly more frequently seen in Pi-deficiency phlegm-dampness syndrome and Pi-Shen yang-deficiency syndrome. Family heritability could be seen in each syndrome patterns. Among them, female heritability was more often seen in Shen-deficiency blood-stasis syndrome, while male heritability was more often seen in Shen-yin deficiency syndrome.
Shen-deficiency blood-stasis syndrome, Pi-deficiency phlegm-dampness syndrome, Pi-Shen yang-deficiency syndrome, and Shen-yin deficiency syndrome were most frequently seen in PCOS patients. The sex hormones (including 6 items), FBS, FIN, WHR and BMI, etc. were correlated with each Chinese medicine syndrome pattern to various extents, which could be taken as reference in Chinese medicine syndrome differentiation.
研究多囊卵巢综合征（PCOS）患者中医证型及其相关症状的分布规律，以及中医证型与PCOS相关参数之间的可能相关性，从而为疗效评价中选择合适的指标提供指导。
采用临床流行病学方法和数理统计学方法，对228例PCOS患者的中医证型进行研究，总结中医证型的分布特征。
肾虚血瘀证是PCOS患者中最常见的证型，其次为脾虚痰湿证、脾肾阳虚证和肾阴虚证。血清卵泡刺激素（FSH）水平与脾肾阳虚证呈正相关。空腹血糖（FBS）、腰臀比（WHR）、体重指数（BMI）、空腹胰岛素（FIN）和多毛评分与脾虚痰湿证呈正相关。血清催乳素（PRL）、雌二醇（E2）水平与气滞血瘀证呈正相关。血清孕酮（PRG）水平、FSH、FIN、BMI、痤疮评分与肝郁血热证呈正相关。黄体生成素（LH）与肾虚血瘀证呈正相关。此外，LH/FSH>3在脾虚痰湿证和脾肾阳虚证中可能更常见。各证型均可见家族遗传性。其中，肾虚血瘀证女性遗传性更常见，而肾阴虚证男性遗传性更常见。
肾虚血瘀证、脾虚痰湿证、脾肾阳虚证和肾阴虚证是PCOS患者中最常见的证型。性激素（包括6项）、FBS、FIN、WHR和BMI等与各中医证型有不同程度的相关性，可作为中医辨证的参考。
