Li Wei-Hong, Li Wen-Jie, Xue Yan
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Sep;36(9):1061-1064.
Objective To observe the correlation between serum sex hormone levels and different syndrome types of Chinese medicine (CM) in dysfunctional uterine bleeding (DUB) patients. Methods Totally 532 DUB patients were classified into 10 different syndrome types according to syndrome typing theories of CM, including Gan-depression transforming heat syndrome, Shen deficiency blood sta- sis syndrome, Shen-yin deficiency syndrome, Pi-Shen deficiency syndrome, qi and yin deficiency syndrome, qi and blood deficiency syndrome, Pi deficiency syndrome, qi stagnation blood stasis syndrome, damp-heat syndrome, yin deficiency blood heat syndrome. Besides, 6 serum levels of sex hormone were measured including follicular stimulating hormone (FSH) , luteinizing hormone (LH) , estradiol (E₂) , progesterone (P) , testerone (T) , and prolactin (PRL) in patients with different syndrome types. Correlation study between syndrome types and sex hormones were performed using Logistic regression analysis. Results The distributions of DUB in CM were sequenced from high to low as uterine bleeding, menostaxis, preceded menstrual cycle, intermenstrual bleeding, and menorrhagia. The distributions of syndrome types were sequenced from high to low as yin deficiency blood heat syndrome, qi and blood deficiency syndrome, qi stagnation blood stasis syndrome, Shen-yin deficiency syndrome, Pi-Shen deficiency syndrome, Gan-depression transforming heat syndrome, Pi deficiency syndrome, Shen deficiency blood stasis syndrome, qi and yin deficiency syndrome, damp-heat syndrome. PRL level was positively correlated with Gan-depression transforming heat syndrome in the ratio of 1. 117 (P <0. 05). FSH level was positively correlated with Shen-yin deficiency syndrome in the ratio of 1. 327 (P <0. 05). LH level was positively correlated with Pi-Shen deficiency syndrome in the ratio of 1.342 (P <0.05). Conclusions DUB patients with various syndrome types of CM had different levels of sex hormones, with certain-laws manifested. Positive correlation existed between PRL level and Gan-depression transforming heat syn- drome, FSH level and Shen-yin deficiency syndrome, LH level and Pi-Shen deficiency syndrome.
目的 观察功能失调性子宫出血（DUB）患者血清性激素水平与中医不同证型的相关性。方法 将532例DUB患者按照中医辨证理论分为10种不同证型，包括肝郁化热证、肾虚血瘀证、肾阴虚证、脾肾两虚证、气阴两虚证、气血两虚证、脾虚证、气滞血瘀证、湿热证、阴虚血热证。此外，检测不同证型患者血清中6种性激素水平，包括促卵泡生成素（FSH）、促黄体生成素（LH）、雌二醇（E₂）、孕酮（P）、睾酮（T）和催乳素（PRL）。采用Logistic回归分析进行证型与性激素的相关性研究。结果 DUB的中医证型分布由高到低依次为子宫出血、月经先期、月经先后无定期、经间期出血、月经过多。证型分布由高到低依次为阴虚血热证、气血两虚证、气滞血瘀证、肾阴虚证、脾肾两虚证、肝郁化热证、脾虚证、肾虚血瘀证、气阴两虚证、湿热证。PRL水平与肝郁化热证呈正相关，比值为1.117（P<0.05）。FSH水平与肾阴虚证呈正相关，比值为1.327（P<0.05）。LH水平与脾肾两虚证呈正相关，比值为1.342（P<0.05）。结论 不同中医证型的DUB患者性激素水平存在差异，具有一定规律。PRL水平与肝郁化热证、FSH水平与肾阴虚证、LH水平与脾肾两虚证之间存在正相关。
