细菌生物膜在持续性感染中的作用及控制策略。
The role of bacterial biofilm in persistent infections and control strategies.
机构信息
Key Laboratory of Medical Molecular Virology of Ministry of Education and Ministry of Public Health, Shanghai Medical School of Fudan University, Shanghai 200032, China.
出版信息
Int J Oral Sci. 2011 Apr;3(2):66-73. doi: 10.4248/IJOS11022.
Abstract
Bacterial biofilms can be viewed as a specific type of persistent bacterial infection. After initial invasion, microbes can attach to living and non-living surfaces, such as prosthetics and indwelling medical devices, and form a biofilm composed of extracellular polysaccharides, proteins, and other components. In hosts, biofilm formation may trigger drug resistance and inflammation, resulting in persistent infections. The clinical aspects of biofilm formation and leading strategies for biofilm inhibitors will be discussed in this mini-review.
摘要
细菌生物膜可以被视为一种特殊类型的持续性细菌感染。在初始入侵后，微生物可以附着在活体和非活体表面上，如假体和留置医疗器械，并形成由细胞外多糖、蛋白质和其他成分组成的生物膜。在宿主中，生物膜的形成可能会引发药物抗性和炎症，导致持续性感染。本综述将讨论生物膜形成的临床方面和生物膜抑制剂的主导策略。
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