Howard J D, Moo V, Sivalingam P
Department of Anaesthesia, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Anaesth Intensive Care. 2011 Mar;39(2):287-92. doi: 10.1177/0310057X1103900221.
We report three cases of anaphylaxis during anaesthesia confirmed on intradermal testing to be related to patent blue V dye (Guerbet - Chemical Abstract Service 3536-49-0). All three cases were associated with moderate to severe hypotension. Two cases had delayed onset, and two were associated with a rash. None of the cases were associated with bronchospasm. In all three patients the interference with pulse oximetry readings contributed to difficulties in management. We recommend the use of a test dose of blue dye prior to surgery, as suggested in the manufacturer's product information. We also recommend high vigilance for possible allergic reactions when patent blue dyes are used for sentinel lymph node mapping, because the presentations may be atypical and the reduced pulse oximetry readings may be a distraction.
我们报告了3例麻醉期间发生过敏反应的病例，经皮内试验证实与专利蓝V染料（盖博公司 - 化学文摘社编号3536-49-0）有关。所有3例均伴有中度至重度低血压。2例为迟发性发作，2例伴有皮疹。所有病例均未伴有支气管痉挛。在所有3例患者中，脉搏血氧饱和度读数受到干扰给管理带来了困难。我们建议按照制造商产品信息中的建议，在手术前使用试验剂量的蓝色染料。我们还建议在使用专利蓝染料进行前哨淋巴结定位时，要高度警惕可能的过敏反应，因为表现可能不典型，且脉搏血氧饱和度读数降低可能会分散注意力。
