• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

金属纳米粒子的体外细胞毒性和遗传毒性的安全性评估。

Safety assessment of nanoparticles cytotoxicity and genotoxicity of metal nanoparticles in vitro.

机构信息

Health Effects Group, Norwegian Institute for Air Research (NILU), Instituttvn. 18, N-2027 Kjeller, Norway.

出版信息

J Biomed Nanotechnol. 2011 Feb;7(1):20-1. doi: 10.1166/jbn.2011.1180.

DOI:10.1166/jbn.2011.1180
PMID:21485782
Abstract

There is an urgent need to investigate the mechanisms of action of NMs and to develop testing strategies to assess potential environmental and human hazard. Our study has shown that metal nanoparticles such as iron oxide may induce genotoxic effect. It was inferred that coating and surface properties influence NPs cytotoxicity and genotoxicity.

摘要

迫切需要研究纳米材料的作用机制,并制定测试策略来评估其潜在的环境和人类危害。我们的研究表明,氧化铁等金属纳米粒子可能会引起遗传毒性。据推断,涂层和表面特性会影响纳米颗粒的细胞毒性和遗传毒性。

相似文献

1
Safety assessment of nanoparticles cytotoxicity and genotoxicity of metal nanoparticles in vitro.金属纳米粒子的体外细胞毒性和遗传毒性的安全性评估。
J Biomed Nanotechnol. 2011 Feb;7(1):20-1. doi: 10.1166/jbn.2011.1180.
2
Cytotoxic and genotoxic impact of TiO2 nanoparticles on A549 cells.TiO2 纳米颗粒对 A549 细胞的细胞毒性和遗传毒性影响。
J Biomed Nanotechnol. 2011 Feb;7(1):22-3. doi: 10.1166/jbn.2011.1181.
3
Coating-dependent induction of cytotoxicity and genotoxicity of iron oxide nanoparticles.氧化铁纳米颗粒的涂层依赖性细胞毒性和基因毒性诱导
Nanotoxicology. 2015 May;9 Suppl 1:44-56. doi: 10.3109/17435390.2013.847505. Epub 2013 Nov 14.
4
Cytotoxicity and genotoxicity of cadmium oxide nanoparticles evaluated using in vitro assays.使用体外试验评估氧化镉纳米颗粒的细胞毒性和遗传毒性。
Mutat Res Genet Toxicol Environ Mutagen. 2020 Feb-Mar;850-851:503149. doi: 10.1016/j.mrgentox.2020.503149. Epub 2020 Jan 28.
5
Cytotoxicity and genotoxicity of nanosized and microsized titanium dioxide and iron oxide particles in Syrian hamster embryo cells.纳米级和微米级二氧化钛及氧化铁颗粒对叙利亚仓鼠胚胎细胞的细胞毒性和遗传毒性
Ann Occup Hyg. 2012 Jul;56(5):631-44. doi: 10.1093/annhyg/mes006. Epub 2012 Mar 26.
6
Suitability of human and mammalian cells of different origin for the assessment of genotoxicity of metal and polymeric engineered nanoparticles.不同来源的人类和哺乳动物细胞用于评估金属及聚合物工程纳米颗粒遗传毒性的适用性。
Nanotoxicology. 2015 May;9 Suppl 1:57-65. doi: 10.3109/17435390.2014.940407.
7
In vitro toxicological assessment of iron oxide, aluminium oxide and copper nanoparticles in prokaryotic and eukaryotic cell types.氧化铁、氧化铝和铜纳米颗粒在原核和真核细胞类型中的体外毒理学评估。
Drug Chem Toxicol. 2015 Apr;38(2):152-61. doi: 10.3109/01480545.2014.919584. Epub 2014 Jun 4.
8
An automatable platform for genotoxicity testing of nanomaterials based on the fluorometric γ-H2AX assay reveals no genotoxicity of properly surface-shielded cadmium-based quantum dots.一种基于荧光 γ-H2AX 测定法的纳米材料遗传毒性测试自动化平台,并未显示经适当表面屏蔽的基于镉的量子点具有遗传毒性。
Nanoscale. 2019 Jul 18;11(28):13458-13468. doi: 10.1039/c9nr01021a.
9
In vitro detection of in vitro secondary mechanisms of genotoxicity induced by engineered nanomaterials.体外检测工程纳米材料诱导遗传毒性的体外二次机制。
Part Fibre Toxicol. 2019 Feb 13;16(1):8. doi: 10.1186/s12989-019-0291-7.
10
Genotoxicity of ferric oxide nanoparticles in Raphanus sativus: Deciphering the role of signaling factors, oxidative stress and cell death.氧化铁纳米颗粒的遗传毒性在萝卜中的表现:信号因子、氧化应激和细胞死亡作用的阐释。
J Environ Sci (China). 2016 Sep;47:49-62. doi: 10.1016/j.jes.2015.12.037. Epub 2016 Apr 18.

引用本文的文献

1
Inorganic Nanoparticles as Drug Delivery Systems and Their Potential Role in the Treatment of Chronic Myelogenous Leukaemia.无机纳米颗粒作为药物传递系统及其在慢性髓性白血病治疗中的潜在作用。
Technol Cancer Res Treat. 2019 Jan-Dec;18:1533033819853241. doi: 10.1177/1533033819853241.
2
Metal Oxide Nanomaterial QNAR Models: Available Structural Descriptors and Understanding of Toxicity Mechanisms.金属氧化物纳米材料的QNAR模型:可用的结构描述符及毒性机制理解
Nanomaterials (Basel). 2015 Oct 12;5(4):1620-1637. doi: 10.3390/nano5041620.
3
Mutagenic Effects of Iron Oxide Nanoparticles on Biological Cells.
氧化铁纳米颗粒对生物细胞的诱变作用。
Int J Mol Sci. 2015 Sep 30;16(10):23482-516. doi: 10.3390/ijms161023482.
4
Systematic safety evaluation on photoluminescent carbon dots.光致发光碳点的系统安全性评价。
Nanoscale Res Lett. 2013 Mar 8;8(1):122. doi: 10.1186/1556-276X-8-122.
5
Genotoxicity of different nanocarriers: possible modifications for the delivery of nucleic acids.不同纳米载体的遗传毒性:核酸递送的可能修饰
Curr Drug Discov Technol. 2013 Mar;10(1):8-15.