Nanomaterial and Environmental Toxicology Groups, Indian Institute of Toxicology Research (Council of Scientific and Industrial Research, India), P.O. Box 80, M.G. Marg, Lucknow 226001, India.
J Biomed Nanotechnol. 2011 Feb;7(1):91-2. doi: 10.1166/jbn.2011.1217.
Fullerene and their derivatives have many potential new applications. However, there is increasing concern regarding toxicity as very little information is available about fullerene derivatives--protein interactions. In the present work, to identify proteins interacting with chiral fullerene derivatives, Potential Drug Target Database was searched using reverse docking approach. Hypoxanthine phosphoribosyltransferase and Beta-secretase-1 were found to be the most favorable protein targets for fullerene derivatives.
富勒烯及其衍生物具有许多潜在的新应用。然而，由于有关富勒烯衍生物与蛋白质相互作用的信息非常有限，人们越来越关注其毒性。在本研究中，为了鉴定与手性富勒烯衍生物相互作用的蛋白质，采用反向对接方法在潜在药物靶标数据库中进行了搜索。黄嘌呤磷酸核糖基转移酶和β-分泌酶-1被发现是富勒烯衍生物的最有利的蛋白靶标。
