Nanomedicine Research Centre, Department of Pharmaceutics, I.S.F College of Pharmacy, Moga 142001, India.
J Biomed Nanotechnol. 2011 Feb;7(1):137-8. doi: 10.1166/jbn.2011.1238.
The present study aimed to prepare and characterize anti EGFR monoclonal antibody (mab) conjugated Gemcitabine loaded PLGA nanoparticles for their selective delivery to pancreatic cells and evaluation of the systems in vitro. It was observed that direct covalent coupling of antibodies to glutaraldehyde activated nanoparticles is an appropriate method to achieve cell-type specific drug carrier systems based on polymeric nanoparticles that have potential to be applied for targeted chemotherapy in EGFR positive cancer.
本研究旨在制备和表征抗 EGFR 单克隆抗体（mab）偶联吉西他滨载 PLGA 纳米粒，用于其对胰腺细胞的选择性递药，并评估其体外系统。结果表明，抗体与戊二醛活化纳米粒的直接共价偶联是一种获得基于聚合物纳米粒的细胞类型特异性药物载体系统的合适方法，该系统有可能应用于 EGFR 阳性癌症的靶向化疗。
