Nanoformulation Research Laboratory, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India.
J Biomed Nanotechnol. 2011 Feb;7(1):144-5. doi: 10.1166/jbn.2011.1241.
Ganciclovir (GCV) plays an important role in the treatment of ocular viral infections. A high dose results in dose-related toxicity including bone marrow suppression and neutropenia. The aim of the present study was to investigate the comparative potential of different mucoadhesive nano formulations for the topical ocular delivery of Ganciclovir. GCV mucoadhesive Nanoemulsions (GCV-NEs), chitosan nanoparticles (GCV-NPs), GCV mucoadhesive niosomal dispersion (GCV-NDs) were prepared by the reverse-phase evaporation technique. All of the three formulations were evenly round in shape with mean particle size in the range of 23-200 nm. These results indicated the nonirritant and nontoxic nature of the developed formulations. The achieved results may be useful for formulation development of GCV, which could be effective in the treatment of ocular infections by topical instillation.
更昔洛韦（GCV）在治疗眼部病毒感染中起着重要作用。高剂量会导致剂量相关的毒性，包括骨髓抑制和中性粒细胞减少症。本研究旨在探讨不同的黏膜黏附纳米制剂对更昔洛韦局部眼部给药的比较潜力。通过反相蒸发技术制备了更昔洛韦黏膜黏附纳米乳（GCV-NE）、壳聚糖纳米粒（GCV-NP）和更昔洛韦黏膜黏附脂质体分散体（GCV-ND）。这三种制剂均为均匀圆形，平均粒径在 23-200nm 范围内。这些结果表明所开发制剂具有非刺激性和非毒性。研究结果可能有助于更昔洛韦制剂的开发，通过局部滴注可有效治疗眼部感染。
