Singapore Bioimaging Consortium - A*Star - Translational Molecular Imaging, Singapore 138667, Singapore.
Expert Opin Biol Ther. 2011 Jul;11(7):911-20. doi: 10.1517/14712598.2011.575057. Epub 2011 Apr 12.
Cell transplants to replace cells lost due to injury or degenerative diseases, for which there are currently no cures, are being pursued in a wide range of experimental models. Thus, the application of stem cell-based therapies to treat neurodegenerative and traumatic injuries is now a clinical reality. However, the monitoring of cellular grafts, non-invasively, is an important aspect of the ongoing efficacy and safety assessment of cell-based therapies. Hence, there is a need for non-invasive imaging techniques to ensure that transplants are not only administered to the relevant site, but also allow the monitoring of inappropriate cellular migration to improve our understanding of stem cell migration in the context of the whole organism.
This review provides an up to date overview of molecular imaging approaches that have been used for visualizing and tracking transplanted stem cells, in vivo.
It's important to emphasize that the application of molecular imaging to interrogate transplanted cells may require one or even two imaging modalities to provide a reasonable assessment of transplanted cells in specific organs.
细胞移植被广泛应用于各种实验模型，旨在替代因损伤或退行性疾病而丧失的细胞，而目前这些疾病尚无有效的治疗方法。因此，基于干细胞的疗法在治疗神经退行性疾病和创伤方面已成为临床现实。然而，细胞移植的非侵入性监测是正在进行的细胞疗法的疗效和安全性评估的重要方面。因此，需要非侵入性成像技术来确保不仅将移植物施用到相关部位，而且还可以监测不适当的细胞迁移，以提高我们对干细胞在整个生物体中的迁移的理解。
本文综述了用于体内可视化和跟踪移植干细胞的分子成像方法的最新进展。
需要强调的是，应用分子成像来研究移植细胞可能需要一种甚至两种成像方式，才能对特定器官中的移植细胞进行合理评估。
