开放标签的尿苷用于治疗患有双相情感障碍的抑郁青少年。
Open-label uridine for treatment of depressed adolescents with bipolar disorder.
作者信息
Kondo Douglas G, Sung Young-Hoon, Hellem Tracy L, Delmastro Kristen K, Jeong Eun-Kee, Kim Namkug, Shi Xianfeng, Renshaw Perry F
机构信息
The Brain Institute, University of Utah, Salt Lake City, Utah 84108, USA.
出版信息
J Child Adolesc Psychopharmacol. 2011 Apr;21(2):171-5. doi: 10.1089/cap.2010.0054. Epub 2011 Apr 12.
Abstract
This report is an open-label case series of seven depressed adolescents with bipolar disorder treated with uridine for 6 weeks. Treatment response was measured with the Children's Depression Rating Scale-Revised and the Clinical Global Impressions scale. Uridine was associated with decreased depressive symptoms, and was well tolerated by study participants. Further systematic studies of uridine are warranted.
摘要
本报告是一项开放标签的病例系列研究，对7名患有双相情感障碍的抑郁青少年使用尿苷进行了为期6周的治疗。使用儿童抑郁评定量表修订版和临床总体印象量表来衡量治疗反应。尿苷与抑郁症状减轻相关，且研究参与者对其耐受性良好。有必要对尿苷进行进一步的系统研究。
相似文献
1
Open-label uridine for treatment of depressed adolescents with bipolar disorder.开放标签的尿苷用于治疗患有双相情感障碍的抑郁青少年。
J Child Adolesc Psychopharmacol. 2011 Apr;21(2):171-5. doi: 10.1089/cap.2010.0054. Epub 2011 Apr 12.
2
Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients.三乙酰尿苷（TAU）可减轻双相情感障碍患者的抑郁症状并提高其脑内pH值。
Exp Clin Psychopharmacol. 2008 Jun;16(3):199-206. doi: 10.1037/1064-1297.16.3.199.
3
A double-blind, placebo-controlled pilot study of quetiapine for depressed adolescents with bipolar disorder.一项关于喹硫平治疗双相情感障碍抑郁青少年的双盲、安慰剂对照试验性研究。
Bipolar Disord. 2009 Aug;11(5):483-93. doi: 10.1111/j.1399-5618.2009.00728.x.
4
Beneficial acute antidepressant effects of aripiprazole as an adjunctive treatment or monotherapy in bipolar patients unresponsive to mood stabilizers: results from a 16-week open-label trial.阿立哌唑作为辅助治疗或单一疗法对双相情感障碍患者（对心境稳定剂无反应）的有益急性抗抑郁作用：一项为期16周的开放标签试验结果
Expert Opin Pharmacother. 2008 Dec;9(18):3145-9. doi: 10.1517/14656560802504490.
5
Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trial.抗胆碱能药物东莨菪碱的抗抑郁疗效：一项随机、安慰剂对照临床试验。
Arch Gen Psychiatry. 2006 Oct;63(10):1121-9. doi: 10.1001/archpsyc.63.10.1121.
6
Relative effectiveness of adjunctive risperidone on manic and depressive symptoms in mixed mania.利培酮辅助治疗混合躁狂症的躁狂和抑郁症状的相对有效性。
Int Clin Psychopharmacol. 2013 Mar;28(2):91-5. doi: 10.1097/YIC.0b013e32835c7590.
7
An open study of lamotrigine in refractory bipolar depression.拉莫三嗪治疗难治性双相抑郁的开放性研究。
Psychiatry Res. 1997 Sep 19;72(2):145-8. doi: 10.1016/s0165-1781(97)00082-6.
8
Chronic depression in bipolar disorder.双相情感障碍中的慢性抑郁
Am J Psychiatry. 2006 Aug;163(8):1337-41; quiz 1478. doi: 10.1176/ajp.2006.163.8.1337.
9
Preliminary study of relationships among measures of depressive symptoms in adolescents with bipolar disorder.双相情感障碍青少年抑郁症状测量指标之间关系的初步研究。
J Child Adolesc Psychopharmacol. 2006 Jun;16(3):327-35. doi: 10.1089/cap.2006.16.327.
10
A factor analytic study in bipolar depression, and response to lamotrigine.双相抑郁的因子分析研究及拉莫三嗪的反应。
CNS Spectr. 2013 Aug;18(4):214-24. doi: 10.1017/S1092852913000291. Epub 2013 May 23.
引用本文的文献
1
Comparative efficacy of mitochondrial agents for bipolar disorder during depressive episodes: a network meta-analysis using frequentist and Bayesian approaches.比较线粒体药物在双相情感障碍抑郁发作中的疗效：基于频繁和贝叶斯方法的网络荟萃分析。
Psychopharmacology (Berl). 2021 Dec;238(12):3347-3356. doi: 10.1007/s00213-021-06019-y. Epub 2021 Nov 9.
2
Targeting Mitochondrial Dysfunction for Bipolar Disorder.针对双相情感障碍的线粒体功能障碍。
Curr Top Behav Neurosci. 2021;48:61-99. doi: 10.1007/7854_2020_152.
3
Mitochondrial Agents for Bipolar Disorder.用于双相障碍的线粒体药物。
Int J Neuropsychopharmacol. 2018 Jun 1;21(6):550-569. doi: 10.1093/ijnp/pyy018.
4
Decreased brain PME/PDE ratio in bipolar disorder: a preliminary (31) P magnetic resonance spectroscopy study.双相情感障碍患者脑内磷酸单酯/磷酸二酯比值降低：一项初步的磷磁共振波谱研究
Bipolar Disord. 2015 Nov;17(7):743-52. doi: 10.1111/bdi.12339. Epub 2015 Oct 19.
5
Frontal lobe bioenergetic metabolism in depressed adolescents with bipolar disorder: a phosphorus-31 magnetic resonance spectroscopy study.双相障碍抑郁青少年额叶脑能量代谢：磷-31 磁共振波谱研究。
Bipolar Disord. 2012 Sep;14(6):607-17. doi: 10.1111/j.1399-5618.2012.01040.x. Epub 2012 Jul 20.
本文引用的文献
1
Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder.双相情感障碍患者前额叶皮质中线粒体复合物I活性及线粒体蛋白的氧化损伤
Arch Gen Psychiatry. 2010 Apr;67(4):360-8. doi: 10.1001/archgenpsychiatry.2010.22.
2
Multinutrient supplement as treatment: literature review and case report of a 12-year-old boy with bipolar disorder.多种营养素补充剂作为治疗方法：一名12岁双相情感障碍男孩的文献综述与病例报告
J Child Adolesc Psychopharmacol. 2009 Aug;19(4):453-60. doi: 10.1089/cap.2008.0157.
3
Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides.口服尿苷和DHA（脑磷脂的循环前体）可增强突触形成。
J Nutr Health Aging. 2009 Mar;13(3):189-97. doi: 10.1007/s12603-009-0056-3.
4
Decreased glutamate/glutamine levels may mediate cytidine's efficacy in treating bipolar depression: a longitudinal proton magnetic resonance spectroscopy study.谷氨酸/谷氨酰胺水平降低可能介导胞苷治疗双相抑郁症的疗效：一项纵向质子磁共振波谱研究。
Neuropsychopharmacology. 2009 Jun;34(7):1810-8. doi: 10.1038/npp.2009.2. Epub 2009 Feb 4.
5
Elevated cerebrospinal fluid lactate concentrations in patients with bipolar disorder and schizophrenia: implications for the mitochondrial dysfunction hypothesis.双相情感障碍和精神分裂症患者脑脊液乳酸浓度升高：对线粒体功能障碍假说的启示
Biol Psychiatry. 2009 Mar 15;65(6):489-94. doi: 10.1016/j.biopsych.2008.11.010. Epub 2008 Dec 21.
6
Synapse formation and cognitive brain development: effect of docosahexaenoic acid and other dietary constituents.突触形成与认知脑发育：二十二碳六烯酸及其他膳食成分的作用
Metabolism. 2008 Oct;57 Suppl 2(Suppl 2):S6-10. doi: 10.1016/j.metabol.2008.07.007.
7
Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients.三乙酰尿苷（TAU）可减轻双相情感障碍患者的抑郁症状并提高其脑内pH值。
Exp Clin Psychopharmacol. 2008 Jun;16(3):199-206. doi: 10.1037/1064-1297.16.3.199.
8
Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders.以谷氨酸能系统为靶点开发用于治疗情绪障碍的新型改良疗法。
Nat Rev Drug Discov. 2008 May;7(5):426-37. doi: 10.1038/nrd2462.
9
Mitochondrially mediated plasticity in the pathophysiology and treatment of bipolar disorder.线粒体介导的可塑性在双相情感障碍病理生理学及治疗中的作用
Neuropsychopharmacology. 2008 Oct;33(11):2551-65. doi: 10.1038/sj.npp.1301671. Epub 2008 Jan 30.
10
Adherence to pharmacological treatment for juvenile bipolar disorder.青少年双相情感障碍药物治疗的依从性。
J Am Acad Child Adolesc Psychiatry. 2007 Jul;46(7):831-9. doi: 10.1097/chi.0b013e31805c7421.
Zotero 插件