Kanai Takahiro, Shiraishi Hirohiko, Yamagata Takanori, Ito Takane, Odaka Jun, Saito Takashi, Aoyagi Jun, Momoi Mariko Y
Department of Pediatrics, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Pediatr Int. 2011 Dec;53(6):906-9. doi: 10.1111/j.1442-200X.2011.03380.x.
Several cytokines have a pathological association with idiopathic steroid-sensitive nephrotic syndrome (ISSNS) in inducing proteinuria or regulating T cells. Because interleukin (IL)-7 plays important roles in regulating T-cell proliferation and sustaining naïve or memory T cells, IL-7 is one of the candidate cytokines in the pathogenesis of ISSNS. Very little is known, however, about the association of IL-7 with ISSNS. To clarify the IL-7 dynamics in children with ISSNS, serum IL-7 level was investigated, from the nephrotic phase before steroid treatment (STx; group A1) to the remission phase with STx (group A2) and without STx (group A3).
Eighteen children with ISSNS were included in the present study. A total of 25 paired samples were analyzed for groups A1 and A2, and a total of 10 paired samples for groups A1, A2, and A3 due to recurrence. Two control groups (with normal urinalysis, group B; or with nephrotic syndrome other than ISSNS, group C), matched for age and gender, were also included. Serum cytokine level was measured on bead-based assay.
Each serum IL-7 level in groups A1 and A3 was higher than each serum IL-7 level of groups C and B, respectively. The group A2 serum IL-7 level was higher than that of group A1. There was no statistical significance of serum IL-7 level between group A1 and group A3.
Serum IL-7 level was elevated in children with ISSNS regardless of the status of the disease. This brings us one step closer to a better understanding of the pathophysiology of ISSNS in children.
几种细胞因子与特发性类固醇敏感性肾病综合征（ISSNS）在诱导蛋白尿或调节T细胞方面存在病理关联。由于白细胞介素（IL）-7在调节T细胞增殖和维持初始或记忆T细胞方面发挥重要作用，IL-7是ISSNS发病机制中的候选细胞因子之一。然而，关于IL-7与ISSNS的关联知之甚少。为了阐明ISSNS患儿的IL-7动态变化，研究了从类固醇治疗（STx）前的肾病期（A1组）到STx后的缓解期（A2组）以及未进行STx的缓解期（A3组）患儿的血清IL-7水平。
本研究纳入了18例ISSNS患儿。由于复发，A1组和A2组共分析了25对样本，A1组、A2组和A3组共分析了10对样本。还纳入了两个年龄和性别匹配的对照组（尿常规正常，B组；或患有ISSNS以外的肾病综合征，C组）。采用基于微珠的检测方法测量血清细胞因子水平。
A1组和A3组的血清IL-7水平分别高于C组和B组的血清IL-7水平。A2组的血清IL-7水平高于A1组。A1组和A3组之间血清IL-7水平无统计学意义。
无论疾病状态如何，ISSNS患儿的血清IL-7水平均升高。这使我们在更好地理解儿童ISSNS的病理生理学方面又迈进了一步。
