Medical Department, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Am J Transplant. 2011 Jun;11(6):1315-9. doi: 10.1111/j.1600-6143.2011.03517.x. Epub 2011 Apr 12.
Reports on quality of life of kidney donors include small populations with variable response rates. The aim was to evaluate quality of life in kidney donors in a large cross-sectional study. Through the Norwegian Renal Registry we contacted all 1984 kidney donors in the period 1963-2007 with a response rate of 76%. All received the Short-Form-36 (SF-36) survey form and a questionnaire specifically designed for kidney donors. SF-36 scores for a subgroup (n = 1414) of kidney donors were not inferior to a general population sample, adjusted for age, gender and education. When asked to reconsider, a majority stated that they still would have consented to donate. Risk factors for having doubts were graft loss in the recipient (OR 3.1, p < 0.001), medical problems after donation (OR 3.7, p < 0.001), unrelated donor (OR 2.2, p = 0.01) and less than 12 years since donation (OR 1.8, p = 0.04). Older age at donation was associated with lower risk (OR 0.98, p = 0.03). Compared with other donors, those expressing doubts had inferior SF-36 scores. Norwegian kidney donors are mostly first-degree relatives. They are fully reimbursed and offered life-long follow-up. All inhabitants are provided universal healthcare. This should be considered when extrapolating these results to other countries.
报告显示，肾移植受者的生活质量包括人群规模较小和应答率可变等特点。本研究旨在通过大样本横断面研究评估肾移植供者的生活质量。我们通过挪威肾脏登记处联系了 1963 年至 2007 年间的所有 1984 名肾移植供者，应答率为 76%。所有供者均收到了简明健康调查问卷 36 项简表(SF-36)和一份专门为肾移植供者设计的问卷。1414 名肾移植供者的 SF-36 评分与一般人群样本相当，经年龄、性别和教育程度校正后差异无统计学意义。当被问及是否会重新考虑时，大多数人表示仍会同意捐献。有疑虑的风险因素包括受者移植物丢失(OR 3.1，p < 0.001)、捐献后出现医疗问题(OR 3.7，p < 0.001)、非亲缘供者(OR 2.2，p = 0.01)和捐献后不到 12 年(OR 1.8，p = 0.04)。供者年龄较大与风险降低相关(OR 0.98，p = 0.03)。与其他供者相比，有疑虑的供者 SF-36 评分较低。挪威的肾移植供者主要是一级亲属。他们可以获得全额报销，并接受终身随访。所有居民都可以享受全民医疗保健。在将这些结果推广到其他国家时，应考虑到这一点。
