Department of Anatomy, Naresuan University, Phitsanulok, Thailand.
Andrologia. 2011 Aug;43(4):278-82. doi: 10.1111/j.1439-0272.2010.01071.x. Epub 2011 Feb 25.
Methamphetamine has been reported to be an important drug in the field of reproductive toxicology. The aim of this study was to investigate the effects of methamphetamine administrations on sperm morphology, sperm concentration and apoptotic activity inside seminiferous tubule in male rats. Rats were administered a dose of 8 mg kg(-1) , intraperitoneally (IP), for acute group and a dose of 4 mg kg(-1) , IP, once daily for 14 days for sub-acute group. Percentage of normal sperm morphology was decreased in acute group when compared with control. Total numbers of sperm count were significantly decreased in acute and sub-acute groups. Apoptotic activities were most abundant in the seminiferous tubules of acute treated animals with a highly significant increase in the number of apoptotic cells per tubule. Those effects of methamphetamine seem to be dose-dependent. The results suggest that methamphetamine not only works as drug of abuse in central nervous system, but also in gametogenesis of males.
甲基苯丙胺已被报道是生殖毒理学领域的一种重要药物。本研究旨在探讨甲基苯丙胺给药对雄性大鼠精子形态、精子浓度和曲细精管内凋亡活性的影响。大鼠急性组给予 8mg/kg 剂量，腹腔内（IP）给药；亚急性组给予 4mg/kg 剂量，每日一次，连续 14 天 IP 给药。与对照组相比，急性组正常精子形态的百分比下降。急性组和亚急性组的精子总数明显减少。急性处理动物的曲细精管中凋亡活性最为丰富，每个曲细精管中的凋亡细胞数量显著增加。这些甲基苯丙胺的作用似乎是剂量依赖性的。结果表明，甲基苯丙胺不仅在中枢神经系统中作为滥用药物，而且在男性配子发生中也有作用。
