Department of Pharmaceutical Toxicology, Faculty of Pharmacy, University of Inonu, Malatya, Turkey.
Andrologia. 2012 Jun;44(3):181-6. doi: 10.1111/j.1439-0272.2010.01127.x. Epub 2011 Mar 7.
In this study, the beneficial effect of chrysin, a natural flavonoid currently under investigation due to its important biological activities, on reproductive system of rats was investigated. Rats (n = 16) were divided randomly into two equal groups. Rats in control group were given corn oil as carrier. Chrysin was orally administered at the dose of 50 mg kg(-1) per day by gavages, and it was dissolved in corn oil for 60 days. Tissue thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) levels, antioxidant enzyme activity (CAT, SOD and GSH-Px), sperm parameters (motility, concentration and abnormal sperm rate), reproductive organ weight (testes, epididymis, vesicula seminalis, prostate) and serum testosterone levels were determined in the rats. Our results indicated that chrysin significantly increased GSH, CAT, GSH-Px and CuZn-SOD levels, but did not change the formation of TBARS significantly. In addition, sperm motility, sperm concentration and serum testosterone levels significantly increased, whereas abnormal sperm rate significantly decreased with chrysin treatment. In conclusion, it is suggested that treatment with chrysin can positively affect the reproductive system in rats, and it can be used for the treatment of male infertility.
在这项研究中，我们研究了天然黄酮类化合物白杨素对大鼠生殖系统的有益作用。将 16 只大鼠随机均分为两组。对照组大鼠给予玉米油作为载体。白杨素以 50mg/kg/天的剂量经灌胃给药，溶于玉米油中，共给药 60 天。测定大鼠组织的硫代巴比妥酸反应物质（TBARS）和谷胱甘肽（GSH）水平、抗氧化酶活性（CAT、SOD 和 GSH-Px）、精子参数（活力、浓度和异常精子率）、生殖器官重量（睾丸、附睾、精囊、前列腺）和血清睾酮水平。我们的结果表明，白杨素显著增加 GSH、CAT、GSH-Px 和 CuZn-SOD 水平，但对 TBARS 的形成没有显著影响。此外，白杨素治疗可显著提高精子活力、浓度和血清睾酮水平，而异常精子率显著降低。总之，提示白杨素治疗可对大鼠生殖系统产生积极影响，可用于治疗男性不育。
