Mittal Pooja, Dhankhar Sanchit, Chauhan Samrat, Garg Nitika, Bhattacharya Tanima, Ali Maksood, Chaudhary Anis Ahmad, Rudayni Hassan Ahmad, Al-Zharani Mohammed, Ahmad Wasim, Khan Salah Ud-Din, Singh Thakur Gurjeet, Mujwar Somdutt
Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, India.
Ganpati Institute of Pharmacy, Bilaspur 135102, India.
Pharmaceuticals (Basel). 2023 Jun 21;16(7):908. doi: 10.3390/ph16070908.
The neurodegenerative condition known as Parkinson's disease (PD) is brought on by the depletion of dopaminergic neurons in the basal ganglia, which is the brain region that controls body movement. PD occurs due to many factors, from which one of the acknowledged effects of oxidative stress is pathogenic pathways that play a role in the development of Parkinson's disease. Antioxidants, including flavonoids, vitamins E and C, and polyphenolic substances, help to reduce the oxidative stress brought on by free radicals. Consequently, this lowers the risk of neurodegenerative disorders in the long term. Although there is currently no cure for neurodegenerative illnesses, these conditions can be controlled. The treatment of this disease lessens its symptoms, which helps to preserve the patient's quality of life. Therefore, the use of naturally occurring antioxidants, such as polyphenols, which may be obtained through food or nutritional supplements and have a variety of positive effects, has emerged as an appealing alternative management strategy. This article will examine the extent of knowledge about antioxidants in the treatment of neurodegenerative illnesses, as well as future directions for research. Additionally, an evaluation of the value of antioxidants as neuroprotective agents will be provided.
被称为帕金森病（PD）的神经退行性疾病是由基底神经节中多巴胺能神经元的耗竭引起的，基底神经节是控制身体运动的脑区。帕金森病的发生是由多种因素导致的，其中氧化应激的公认影响之一是在帕金森病发展过程中起作用的致病途径。抗氧化剂，包括黄酮类化合物、维生素E和C以及多酚类物质，有助于减少自由基带来的氧化应激。因此，从长远来看，这降低了神经退行性疾病的风险。虽然目前神经退行性疾病无法治愈，但这些疾病可以得到控制。这种疾病的治疗减轻了其症状，有助于维持患者的生活质量。因此，使用天然存在的抗氧化剂，如多酚类物质，它们可以通过食物或营养补充剂获得，并且有多种积极作用，已成为一种有吸引力的替代管理策略。本文将探讨关于抗氧化剂在神经退行性疾病治疗方面的知识范围以及未来的研究方向。此外，还将对抗氧化剂作为神经保护剂的价值进行评估。
