Department of Brain and Cognitive Sciences and Center for Visual Science, University of Rochester, Rochester, NY 14627, USA.
J Int Neuropsychol Soc. 2011 Jul;17(4):654-62. doi: 10.1017/S1355617711000452.
We analyzed verbal episodic memory learning and recall using the Logical Memory (LM) subtest of the Wechsler Memory Scale-III to determine how gender differences in AD compare to those seen in normal elderly and whether or not these differences impact assessment of AD. We administered the LM to both an AD and a Control group, each comprised of 21 men and 21 women, and found a large drop in performance from normal elders to AD. Of interest was a gender interaction whereby the women's scores dropped 1.6 times more than the men's did. Control women on average outperformed Control men on every aspect of the test, including immediate recall, delayed recall, and learning. Conversely, AD women tended to perform worse than AD men. Additionally, the LM achieved perfect diagnostic accuracy in discriminant analysis of AD versus Control women, a statistically significantly higher result than for men. The results indicate the LM is a more powerful and reliable tool in detecting AD in women than in men.
我们使用韦氏记忆量表第三版的逻辑记忆（LM）子测验分析了言语情节记忆学习和回忆，以确定 AD 中的性别差异与正常老年人中的性别差异相比如何，以及这些差异是否会影响 AD 的评估。我们对 AD 组和对照组的每位 21 名男性和 21 名女性进行了 LM 测试，发现从正常老年人到 AD 患者的表现有很大的下降。有趣的是，存在性别交互作用，即女性的分数下降幅度比男性高 1.6 倍。在测试的各个方面，包括即时回忆、延迟回忆和学习，对照组女性的平均表现均优于对照组男性。相反，AD 女性的表现往往不如 AD 男性。此外，LM 在 AD 与对照组女性的判别分析中实现了完美的诊断准确性，这一结果明显高于男性。结果表明，在检测女性 AD 方面，LM 是比男性更强大、更可靠的工具。
