Larumbe R
Departamento de Neurología y Neurocirugía, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra.
Rev Med Univ Navarra. 1997 Jan-Mar;41(1):6-11.
We attempt to determine the utility of CERAD in detecting early Alzheimer's disease (AD). CERAD battery was administered to a group of 14 control subjects, 12 patients with possible dementia prodromes and to patients with Alzheimer's disease stratified according to severity (16 mild, 8 moderate). Other measures as some subtest of the Wechsler memory scale and the Rey Complex Figure Test were also applied. Delayed recall as well as logical memory of Wechsler memory scale were found to be the best discriminators for detecting very mild cases of AD (Prodromes) (p < 0.05). None of the memory test proved of value in staging the disorder. Visuospatial functions are better determinants of the progression of the illness. Fluency also distinguish between control subjects and very mild cases. These findings suggest that delayed recall memory and probably executive function are the most useful and sensitive indicators of Alzheimer's disease.
我们试图确定临床痴呆评定量表（CERAD）在检测早期阿尔茨海默病（AD）方面的效用。对14名对照受试者、12名可能患有痴呆前驱症状的患者以及根据严重程度分层的阿尔茨海默病患者（16名轻度、8名中度）进行了CERAD成套测试。还应用了其他一些测试，如韦氏记忆量表的某些子测试和雷氏复杂图形测试。发现韦氏记忆量表的延迟回忆以及逻辑记忆是检测AD极轻微病例（前驱症状）的最佳鉴别指标（p<0.05）。没有一项记忆测试被证明对该疾病的分期有价值。视觉空间功能是疾病进展的更好决定因素。流畅性也能区分对照受试者和极轻微病例。这些发现表明，延迟回忆记忆以及可能的执行功能是阿尔茨海默病最有用和最敏感的指标。
