Allenspach Karin
Royal Veterinary College, University of London, Hawkshead Lane, North Mymms AL9 7PT, UK.
Vet Clin North Am Small Anim Pract. 2011 Mar;41(2):345-60. doi: 10.1016/j.cvsm.2011.01.004.
The mucosal immune system is at the forefront of defense against invading pathogens, but at the same time, it must maintain tolerance toward commensals and food antigens in the intestinal lumen. The interplay between the innate immune response and commensal microorganisms is essential to maintaining this balance. Great progress has been made in identifying some of the genetic predispositions underlying inflammatory bowel disease in certain breeds, such as the German shepherd dog. Several immunologic markers are discussed with respect to their clinical usefulness in the diagnosis and management of inflammatory bowel disease.
黏膜免疫系统处于抵御入侵病原体的前沿，但与此同时，它必须对肠道内的共生菌和食物抗原保持耐受。先天免疫反应与共生微生物之间的相互作用对于维持这种平衡至关重要。在确定某些品种（如德国牧羊犬）炎症性肠病的一些遗传易感性方面已经取得了很大进展。讨论了几种免疫标志物在炎症性肠病诊断和管理中的临床实用性。
