Kanzaki Masato, Kikkawa Takuma, Maeda Hideyuki, Kondo Mitsuko, Isaka Tamami, Shimizu Toshihide, Murasugi Masahide, Onuki Takamasa
Department of Surgery I, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
Interact Cardiovasc Thorac Surg. 2011 Jul;13(1):16-20. doi: 10.1510/icvts.2010.260067. Epub 2011 Apr 12.
Idiopathic interstitial pneumonias (IIPs) are diffuse lung diseases of unknown cause. Morbidity and mortality are high in patients with IIPs who have undergone lung resection. Postoperative acute exacerbation (PAE) of IIPs is one of the fatal complications after lung resection. From January 2001 to October 2009, 758 consecutive patients with lung cancer who had undergone lung resection at Tokyo Women's Medical University Hospital were investigated retrospectively. Forty (5.3%) of 758 patients had IIPs. PAE of IIPs was developed in 12 of the patients with IIPs. There were no significant differences in the age, gender, operation methods, histology, and pathological stage in the patients with or without PAE of IIPs. Three patients died of uncontrollable PAE of IIPs in hospital. The 30-day mortality of patients with PAE of IIPs in the last nine-year period has clearly decreased compared with the 30-day mortality of patients with PAE of IIPs between January 1996 and December 2000. PAE of IIPs causes high mortality. It is very difficult to predict the occurrence of PAE of IIPs. More efforts are required to develop strategies to prevent PAE of IIPs.
特发性间质性肺炎（IIPs）是病因不明的弥漫性肺疾病。接受肺切除手术的IIPs患者的发病率和死亡率很高。IIPs术后急性加重（PAE）是肺切除术后的致命并发症之一。对2001年1月至2009年10月期间在东京女子医科大学医院连续接受肺切除手术的758例肺癌患者进行了回顾性调查。758例患者中有40例（5.3%）患有IIPs。12例IIPs患者发生了IIPs的PAE。发生或未发生IIPs的PAE患者在年龄、性别、手术方式、组织学和病理分期方面无显著差异。3例患者在医院死于无法控制的IIPs的PAE。与1996年1月至2000年12月期间IIPs的PAE患者的30天死亡率相比，过去九年中IIPs的PAE患者的30天死亡率明显下降。IIPs的PAE导致高死亡率。预测IIPs的PAE的发生非常困难。需要付出更多努力来制定预防IIPs的PAE的策略。
