印度尼西亚 5 岁以下儿童呼吸道合胞病毒下呼吸道感染的流行病学。

The epidemiology of respiratory syncytial virus lower respiratory tract infections in children less than 5 years of age in Indonesia.

机构信息

Section of Infectious Diseases, Department of Pediatrics, University of Colorado at Denver Health Sciences Center and The Children's Hospital, Denver, CO, USA.

出版信息

Pediatr Infect Dis J. 2011 Sep;30(9):778-84. doi: 10.1097/INF.0b013e318218ab9e.

DOI:10.1097/INF.0b013e318218ab9e

PMID:21487330

Abstract

BACKGROUND

Although the epidemiology of respiratory syncytial virus (RSV) lower respiratory tract infections (LRI) is well known in industrialized countries, the burden in developing Asian countries is not well studied.

METHODS

To define the burden of RSV disease in children <5 years of age in rural and urban Indonesia, infants and children were enrolled from peri-urban and rural subdistricts, in the following 2 cohorts: (a) a cross-sectional cohort of approximately 100 children from each of 2 subdistricts in the following 5 age groups: 3 to 5, 6 to 8, 9 to 11, 12 to 23, and 24 to 48 months; (b) a birth cohort of all newborns in both subdistricts during the 28 months of the study. All subjects were visited weekly at home. Children with World Health Organization-defined LRI or wheezing had a nasal wash for detection of RSV using an enzyme immunoassay and polymerase chain reaction.

RESULTS

Of the 2014 children studied, 1074 were in the cross-sectional and 940 in the newborn cohorts. Of the 802 episodes of LRI, 163 were caused by RSV. The RSV LRI incidence per 1000 child-years (C-Y) was higher in rural areas (57.25 vs. 38.54), P < 0.05. No RSV LRI occurred in the first 2 months of life and the peak incidence was in the 6- to 8-month-old infants (103/1000 C-Y). The rates were lowest in those <6 months, 16.5 per 1000 C-Y, compared with 83.1 per 1000 C-Y in those 6 to 11 months of age (P < 0.001), 66.99 in those 12 to 23 months of age, and 28.1 in 2- to 5-year-olds.

CONCLUSIONS

In Indonesia, the incidence of RSV LRI in the first 6 months of life is relatively low with most disease occurring in older children.

摘要

背景

虽然呼吸道合胞病毒（RSV）下呼吸道感染（LRI）在工业化国家的流行病学情况广为人知，但发展中亚洲国家的疾病负担尚未得到充分研究。

方法

为了明确印度尼西亚农村和城市地区 5 岁以下儿童 RSV 疾病的负担，我们在以下 2 个队列中招募了来自城市周边和农村地区的婴儿和儿童：（a）来自 2 个农村地区的每个年龄组约 100 名儿童的横断面队列：3 至 5、6 至 8、9 至 11、12 至 23 和 24 至 48 个月；（b）研究期间的 28 个月内，两个地区所有新生儿的出生队列。所有受试者每周在家中接受访问。患有世界卫生组织定义的 LRI 或喘息的儿童进行鼻冲洗，使用酶免疫测定法和聚合酶链反应检测 RSV。

结果

在研究的 2014 名儿童中，1074 名儿童参加了横断面队列，940 名儿童参加了新生儿队列。在 802 例 LRI 发作中，有 163 例由 RSV 引起。农村地区 RSV 下呼吸道感染每 1000 名儿童年（C-Y）的发病率较高（57.25 比 38.54），P<0.05。在生命的头 2 个月没有发生 RSV 下呼吸道感染，发病率最高的是 6 至 8 个月龄婴儿（103/1000 C-Y）。在<6 个月的婴儿中，发病率最低，为每 1000 C-Y 16.5 例，而在 6 至 11 个月的婴儿中为每 1000 C-Y 83.1 例（P<0.001），在 12 至 23 个月的婴儿中为每 1000 C-Y 66.99 例，在 2 至 5 岁的儿童中为每 1000 C-Y 28.1 例。