Gaddam Sainath, Pablani Lata, Chainani Vinod, Kavuda Ravi Raj, Nagrani Tarun, Abou Rjaili Georges, Dhar Meekoo, Lafferty James C
Department of Internal Medicine, Oncology and Cardiology, Staten Island University Hospital, New York, USA.
Clin Med Insights Cardiol. 2011 Mar 14;5:29-33. doi: 10.4137/CMC.S6130.
A 50 year old male HIV patient on antiretroviral therapy was admitted for chest pain. Upon admission, the patient was found to have elevated cardiac enzymes, acute thrombocytopenia, hemolytic anemia, acute pancreatitis and acute renal failure. The patient was diagnosed with thrombotic thrombocytopenic purpura/haemolytic uremic syndrome and emergency plasma exchange therapy was initiated along with aspirin, beta-blockers, steroids, and antiretroviral therapy. Patient responded well and demonstrated complete resolution of ischemic cardiomyopathy with left ventricular ejection fraction improving from 35% to 55% by the time of discharge. Essentially, prompt diagnosis and treatment can reverse cardiac damage induced by thrombotic thrombocytopenic purpura.
一名接受抗逆转录病毒治疗的50岁男性艾滋病患者因胸痛入院。入院时，发现该患者心肌酶升高、急性血小板减少、溶血性贫血、急性胰腺炎和急性肾衰竭。该患者被诊断为血栓性血小板减少性紫癜/溶血尿毒综合征，并开始进行紧急血浆置换治疗，同时使用阿司匹林、β受体阻滞剂、类固醇和抗逆转录病毒疗法。患者反应良好，出院时缺血性心肌病完全缓解，左心室射血分数从35%提高到55%。从本质上讲，及时诊断和治疗可以逆转血栓性血小板减少性紫癜引起的心脏损伤。
