肥大细胞与辅助性T淋巴细胞之间的同源相互作用。
Cognate interactions between mast cells and helper T lymphocytes.
作者信息
Valitutti Salvatore, Espinosa Eric
机构信息
INSERM; U563; Centre de Physiopathologie de Toulouse Purpan; Section Dynamique moléculaire des interactions lymphocytaires; Toulouse, France; and Université Toulouse III Paul-Sabatier; Toulouse, France.
出版信息
Self Nonself. 2010 Apr;1(2):114-122. doi: 10.4161/self.1.2.11795. Epub 2010 Mar 17.
Abstract
Mast cells are key effectors in allergy and inflammation. Endowed with a large panel of surface receptors and a huge arsenal of bioactive mediators, they readily communicate with various cellular partners during innate and adaptive immune responses. Recent lines of evidence show that mast cells are also able to establish cognate interactions with helper T lymphocytes for antigen presentation and bidirectional cell-cell cooperation. In this short review we focus on the role of mast cells as unconventional antigen presenting cells for helper T lymphocytes. We discuss how looking at mast cell biology from this new angle can help to better understand their pleiotropic role in health and disease.
摘要
肥大细胞是过敏和炎症反应中的关键效应细胞。它们具有大量的表面受体和丰富多样的生物活性介质库，在先天性和适应性免疫反应过程中能轻松地与各种细胞伙伴进行交流。最近的一系列证据表明，肥大细胞还能够与辅助性T淋巴细胞建立同源相互作用，以进行抗原呈递和双向细胞间合作。在这篇简短的综述中，我们重点关注肥大细胞作为辅助性T淋巴细胞的非常规抗原呈递细胞的作用。我们讨论了从这个新角度审视肥大细胞生物学如何有助于更好地理解它们在健康和疾病中的多效性作用。
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