Intensive Care Division, Department of Anesthesiology and Intensive Care, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kamigyo-ku, Kyoto, 602-8566, Japan.
J Anesth. 2011 Jun;25(3):321-9. doi: 10.1007/s00540-011-1130-7. Epub 2011 Apr 13.
Perioperative fast-track management has gained wide acceptance in the field of neonatal corrective heart surgery. We have examined its impact on morbidity outcomes.
Between 1997 and 2009, 52 consecutive neonates underwent corrective repair of congenital heart defects on cardiopulmonary bypass. Fast-track management was introduced in 2006 with the aim of simplifying care; it includes early postoperative extubation with low-dose fentanyl and an pulse oximeter oxygen saturation (SpO(2)) target of ≤ 95%, early removal of indwelling lines, and early introduction of early enteral feeding. This was a retrospective review of the medical records in which perioperative characteristics and outcomes of patients operated on prior to the introduction of fast-track management care (controls, group C) were compared with those operated on following its introduction (fast-track group, group F).
Intraoperative fentanyl was administered in significantly lower doses in group F (29.5 ± 11.5 μg/kg) than in group C (65.6 ± 34.0 μg/kg) (p < 0.001). The median number of days of postoperative mechanical ventilation and inotrope administration was significantly lower in group F (2 and 4 days, respectively) than in group C (9 and 9 days, respectively) (p < 0.001 and p = 0.003). More patients (p < 0.001) in group F (56.3%) than in group C (0%) was extubated within <24 h. The median number of days to postoperative weight recovery was significantly lower in group F (16 days) than in group C (29 days) (p = 0.003). Finally, the median number of days in the Intensive Care Unit was significantly lower (p = 0.01) in group F than in group C (16 vs. 26 days, respectively). Mortality in group F was 0% versus 17% in group C (p = 0.21).
Fast-track management with simple care for neonates undergoing complete biventricular repair of congenital heart defects was associated with better postoperative recovery.
在新生儿矫正心脏手术领域,围手术期快速通道管理已得到广泛认可。我们研究了其对发病率结果的影响。
1997 年至 2009 年期间,52 例连续新生儿在体外循环下行先天性心脏缺陷矫正手术。2006 年引入快速通道管理,旨在简化护理;包括术后早期拔管,低剂量芬太尼和脉搏血氧饱和度(SpO2)目标值≤95%,尽早拔除留置线,并尽早开始肠内喂养。这是一项回顾性病历审查,比较了在引入快速通道管理护理之前接受手术的患者(对照组,C 组)与之后接受手术的患者(快速通道组,F 组)的围手术期特征和结果。
F 组术中芬太尼的用量明显低于 C 组(29.5±11.5μg/kg 比 65.6±34.0μg/kg)(p<0.001)。F 组术后机械通气和血管加压素使用的中位天数明显低于 C 组(分别为 2 天和 4 天)(p<0.001 和 p=0.003)。F 组(56.3%)比 C 组(0%)更多的患者(p<0.001)在 24 小时内拔管。F 组术后体重恢复的中位天数明显低于 C 组(16 天比 29 天)(p=0.003)。最后,F 组在重症监护病房的中位天数明显低于 C 组(p=0.01)(16 天比 26 天)。F 组的死亡率为 0%,C 组为 17%(p=0.21)。
对于接受完全双心室修复先天性心脏缺陷的新生儿,采用简单护理的快速通道管理与术后恢复更好相关。