Gout Laboratory, Medical School Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
Rheumatol Int. 2012 Jun;32(6):1805-7. doi: 10.1007/s00296-011-1936-5. Epub 2011 Apr 13.
To identify association of IL18-607 C/A and -137 G/C polymorphism with susceptibility to gout in Chinese Han male population, We evaluate the genetic contribution of the IL18-607 C/A and -137 G/C polymorphism in 202 gout male patients and 493 gout-free control of Chinese Han population by allele-specific polymerase chain reaction assay. Our results reveal no significant association between the polymorphisms -607C/A and -137G/C in IL18 with gout. Our study might suggest that -607 C/A and -137 G/C polymorphisms in the promoter of IL18 are not associated with susceptibility to gout and thus do not play a major role in the development of gout in the Chinese Han male population.
为了确定白细胞介素 18（IL18）-607 C/A 和 -137 G/C 多态性与中国汉族男性痛风易感性的关联，我们采用等位基因特异性聚合酶链反应（PCR）方法，评估了 IL18-607 C/A 和 -137 G/C 多态性在 202 例痛风男性患者和 493 例非痛风对照中的遗传贡献。我们的结果显示，白细胞介素 18（IL18）中的多态性 -607C/A 和 -137G/C 与痛风之间没有显著关联。我们的研究提示，IL18 启动子中的 -607 C/A 和 -137 G/C 多态性与痛风易感性无关，因此在中国汉族男性人群中，它们在痛风的发生发展中不起主要作用。
