白细胞介素 18 基因-607 C/A 和-137 G/C 多态性与中国汉族男性痛风易感性无关。
Lack of association of -607 C/A and -137 G/C polymorphisms in interleukin 18 gene with susceptibility to gout disease in Chinese Han male population.
机构信息
Gout Laboratory, Medical School Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
出版信息
Rheumatol Int. 2012 Jun;32(6):1805-7. doi: 10.1007/s00296-011-1936-5. Epub 2011 Apr 13.
Abstract
To identify association of IL18-607 C/A and -137 G/C polymorphism with susceptibility to gout in Chinese Han male population, We evaluate the genetic contribution of the IL18-607 C/A and -137 G/C polymorphism in 202 gout male patients and 493 gout-free control of Chinese Han population by allele-specific polymerase chain reaction assay. Our results reveal no significant association between the polymorphisms -607C/A and -137G/C in IL18 with gout. Our study might suggest that -607 C/A and -137 G/C polymorphisms in the promoter of IL18 are not associated with susceptibility to gout and thus do not play a major role in the development of gout in the Chinese Han male population.
摘要
为了确定白细胞介素 18（IL18）-607 C/A 和 -137 G/C 多态性与中国汉族男性痛风易感性的关联，我们采用等位基因特异性聚合酶链反应（PCR）方法，评估了 IL18-607 C/A 和 -137 G/C 多态性在 202 例痛风男性患者和 493 例非痛风对照中的遗传贡献。我们的结果显示，白细胞介素 18（IL18）中的多态性 -607C/A 和 -137G/C 与痛风之间没有显著关联。我们的研究提示，IL18 启动子中的 -607 C/A 和 -137 G/C 多态性与痛风易感性无关，因此在中国汉族男性人群中，它们在痛风的发生发展中不起主要作用。
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