Miao Zhimin, Li Changgui, Chen Ying, Zhao Shihua, Wang Yangang, Wang Zhongchao, Chen Xinyan, Xu Feng, Wang Fang, Sun Ruixia, Hu Jianxia, Song Wei, Yan Shengli, Wang Cong-Yi
Department of Endocrinology, Medical School Hospital of Qingdao University, Qingdao, China.
J Rheumatol. 2008 Sep;35(9):1859-64. Epub 2008 Jul 15.
To demonstrate the prevalence of hyperuricemia and gout associated with dietary and lifestyle changes and evaluate the implication of metabolic disorders to the development of hyperuricemia.
Data collected from 5,003 subjects randomly recruited from 5 coastal cities (Qingdao, Rizhao, Yantai, Weihai, and Dongying) of Shandong province in Eastern China were analyzed.
Overall, the prevalence for hyperuricemia and gout in the studied populations was 13.19% and 1.14%, respectively. The prevalence was significantly higher in men as compared to women (18.32% vs 8.56% for hyperuricemia, 1.94% vs 0.42% for gout). Hyperuricemia was more common in men over age 30 and in women over age 50. A significant steady increase for the prevalence was noted as compared to the previous published data. Urban residents showed much higher prevalence of hyperuricemia as compared to rural residents (14.9% vs 10.1%, p = 0.004). Similarly, higher prevalence was noted in the developed city compared to the less developed city (18.02 vs 5.3%). These discrepancies were highly correlated with economic development as manifested by the increase of daily consumption of meat and seafood. Additionally, alcohol, overweight or obesity, hypertension, and abnormal triglycerides were highly associated with higher prevalence of hyperuricemia. Moreover, hyperuricemia is likely a risk factor for the development of diabetes mellitus.
There was a remarkable increase for the prevalence of hyperuricemia and gout, which is highly correlated with the development of the economy as manifested by dietary and lifestyle changes.
探讨饮食和生活方式改变相关的高尿酸血症和痛风的患病率，并评估代谢紊乱对高尿酸血症发生发展的影响。
对从中国东部山东省5个沿海城市（青岛、日照、烟台、威海和东营）随机招募的5003名受试者收集的数据进行分析。
总体而言，研究人群中高尿酸血症和痛风的患病率分别为13.19%和1.14%。男性患病率显著高于女性（高尿酸血症：18.32%对8.56%；痛风：1.94%对0.42%）。高尿酸血症在30岁以上男性和50岁以上女性中更为常见。与先前公布的数据相比，患病率显著稳步上升。城市居民高尿酸血症患病率远高于农村居民（14.9%对10.1%，p = 0.004）。同样，发达城市的患病率高于欠发达城市（18.02对5.3%）。这些差异与经济发展高度相关，表现为肉类和海鲜日消费量的增加。此外，饮酒、超重或肥胖、高血压和甘油三酯异常与高尿酸血症患病率较高密切相关。此外，高尿酸血症可能是糖尿病发生发展的一个危险因素。
高尿酸血症和痛风的患病率显著增加，这与饮食和生活方式改变所体现的经济发展高度相关。
