Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
J Behav Med. 2012 Feb;35(1):47-62. doi: 10.1007/s10865-011-9341-9. Epub 2011 Apr 13.
Although neurocognitive impairment is an established risk factor for medication nonadherence, standard neurocognitive tests developed for clinical purposes may not fully capture the complexities of non-adherence behavior or effectively inform theory-driven interventions. Prospective memory, an innovative cognitive construct describing one's ability to remember to do something at a later time, is an understudied factor in the detection and remediation of medication non-adherence. This review orients researchers to the construct of prospective memory, summarizes empirical evidence for prospective memory as a risk factor for non-adherence, discusses the relative merits of current measurement techniques, and highlights potential prospective memory-focused intervention strategies. A comprehensive literature review was conducted of published empirical studies investigating prospective memory and medication adherence. Overall, reviewed studies suggest that prospective memory is an important component of medication adherence, providing incremental ecological validity over established predictors. Findings indicate that prospective memory-based interventions might be an effective means of improving adherence.
虽然神经认知障碍是药物治疗依从性的既定风险因素，但为临床目的开发的标准神经认知测试可能无法完全捕捉到不依从行为的复杂性，也无法有效地为基于理论的干预提供信息。前瞻性记忆是一个创新的认知结构，描述了一个人在以后的某个时间记住要做某事的能力，它是检测和纠正药物不依从性的一个研究不足的因素。本综述使研究人员了解前瞻性记忆的结构，总结了前瞻性记忆作为不依从风险因素的经验证据，讨论了当前测量技术的相对优势，并强调了潜在的以前瞻性记忆为重点的干预策略。对已发表的前瞻性记忆与药物依从性相关的实证研究进行了全面的文献综述。总的来说，综述研究表明，前瞻性记忆是药物依从性的一个重要组成部分，提供了比既定预测因素更具生态有效性的增量。研究结果表明，基于前瞻性记忆的干预措施可能是提高依从性的有效手段。
