Department of Gynecology and Obstetrics, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
Mol Cell Biochem. 2011 Aug;354(1-2):199-205. doi: 10.1007/s11010-011-0819-0. Epub 2011 Apr 13.
OVCA1, a tumor suppressor gene, is deleted or lower expressed in about 80% of ovarian cancer. Over expression of OVCA1 in human ovarian cancer A2780 cells inhibits cell proliferation and arrests cells in G1 stage. However, the fact that the molecular mechanism of OVCA1 inhibits cell growth is presently elusive. Here we investigated the potential signaling pathway induced by over-expression of OVCA1. Our results show that over-expression of human OVCA1 in ovarian cancer cells A2780 leads to down-regulation of cyclin D1, and up-regulation of p16, but no effect on the expression of NF-κB. It indicates that OVCA1 could inhibit the proliferation of ovarian cancer cell A2780 by p16/cyclin D1 pathway, but not by NF-κB.
OVCA1 是一种肿瘤抑制基因，约 80%的卵巢癌中存在 OVCA1 缺失或低表达。在人卵巢癌细胞 A2780 中过表达 OVCA1 可抑制细胞增殖并将细胞阻滞在 G1 期。然而，目前尚不清楚 OVCA1 抑制细胞生长的分子机制。在这里，我们研究了 OVCA1 过表达诱导的潜在信号通路。我们的结果表明，在卵巢癌细胞 A2780 中过表达人 OVCA1 导致细胞周期蛋白 D1 的下调和 p16 的上调，但对 NF-κB 的表达没有影响。这表明 OVCA1 可以通过 p16/细胞周期蛋白 D1 通路抑制卵巢癌细胞 A2780 的增殖，而不是通过 NF-κB。
