Schmidt F A, Fleiner F, Harms L, Bohner G, Erb K, Lüdemann L, Dahlslett B, Göktas O
Department of Otolaryngology - Head and Neck Surgery, University of Berlin, Charité Campus Mitte, Smell and Taste Consultation Service, Berlin, Germany.
Rofo. 2011 Jun;183(6):531-5. doi: 10.1055/s-0031-1273290. Epub 2011 Apr 12.
To examine possible causes for olfactory and gustatory dysfunction in MS patients in a prospective study with MRI.
30 MS patients (21 women, 11 men, 22 - 65 years, Ø 42 years) were examined by MRI. The olfactory bulb (OB) and olfactory brain volume was correlated with the number and volume of MS lesions in the olfactory brain and the non-olfactory brain. Olfactory testing was performed using the Threshold-Discrimination-Identification Test (TDI), and gustatory function was tested using the Taste-Strips-Test (TST).
33 % of the MS patients displayed olfactory dysfunction (8 % of the control group), and 17 % displayed gustatory dysfunction (5 % of the control group). There was a correlation between the olfactory brain volume and the number (r = -0.38, p < 0.05) and volume (r = -0.38, p < 0.05) of MS lesions in the olfactory brain. The olfactory brain volume correlated with the number of MS lesions in the non-olfactory brain (r = -0.48, p < 0.05). The volume of the left OB correlated with the volume of MS lesions in the olfactory brain (r = -0.42, p < 0.05), the number (r = 0.37, p < 0.05) and volume (r = 0.4, p < 0.05) of lesions in the left part of the olfactory brain and with the TST score (r = -0.45, p < 0.05). The TST score correlated with the volume of lesions in the left (r = -0.45, p < 0.05) and right part (r = -0.53, p < 0.05) of the olfactory brain. The TST score correlated with the number of lesions in the non-olfactory brain (r = -0.48, p < 0.05).
The correlation between a higher number and volume of MS lesions in the olfactory brain with a decreased OB and olfactory brain volume could help to explain olfactory and gustatory dysfunction in MS patients. Just the left OB correlated with the number and volume of lesions in the olfactory brain. Manual segmentation was a suitable method for measuring OB and olfactory brain volume.
在一项使用MRI的前瞻性研究中，探究多发性硬化症（MS）患者嗅觉和味觉功能障碍的可能原因。
对30例MS患者（21名女性，11名男性，年龄22 - 65岁，平均42岁）进行MRI检查。嗅球（OB）和嗅脑体积与嗅脑及非嗅脑区域MS病灶的数量和体积相关。嗅觉测试采用阈值 - 辨别 - 识别测试（TDI），味觉功能测试采用味觉试纸测试（TST）。
33%的MS患者存在嗅觉功能障碍（对照组为8%），17%的患者存在味觉功能障碍（对照组为5%）。嗅脑体积与嗅脑区域MS病灶的数量（r = -0.38，p < 0.05）和体积（r = -0.38，p < 0.05）相关。嗅脑体积与非嗅脑区域MS病灶的数量相关（r = -0.48，p < 0.05）。左侧OB的体积与嗅脑区域MS病灶的体积相关（r = -0.42，p < 0.05），与嗅脑左侧部分病灶的数量（r = 0.37，p < 0.05）和体积（r = 0.4，p < 0.05）以及TST评分相关（r = -0.45，p < 0.05）。TST评分与嗅脑左侧（r = -0.45，p < 0.05）和右侧部分（r = -0.53，p < 0.05）病灶的体积相关。TST评分与非嗅脑区域病灶的数量相关（r = -0.48，p < 0.05）。
嗅脑区域MS病灶数量和体积增加与OB及嗅脑体积减小之间的相关性，有助于解释MS患者的嗅觉和味觉功能障碍。仅左侧OB与嗅脑区域病灶的数量和体积相关。手动分割是测量OB和嗅脑体积的合适方法。
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