Haehner Antje, Rodewald Antje, Gerber Johannes C, Hummel Thomas
Department of Neurology, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany.
Arch Otolaryngol Head Neck Surg. 2008 Jun;134(6):621-4. doi: 10.1001/archotol.134.6.621.
To investigate changes of olfactory bulb (OB) volume over time in relation to olfactory function.
Prospective, before-after trial.
Outpatient clinic of a university clinic for otorhinolaryngology.
A total of 20 patients with olfactory loss participated in the study. The duration of olfactory deficits ranged from 3 months to 6 years.
Olfactory function was assessed for phenyl ethyl alcohol odor threshold, odor discrimination, and odor identification. Olfactory bulb volume was determined using magnetic resonance imaging.
In initially hyposmic patients (n = 13), changes in OB volume were found to correlate with odor threshold changes (r = 0.82; P = .001); no such correlation was found for odor discrimination or odor identification.
As demonstrated in a longitudinal study for the first time to our knowledge, the human OB is a highly plastic structure that responds to individual changes in olfactory status.
研究嗅球（OB）体积随时间的变化及其与嗅觉功能的关系。
前瞻性前后对照试验。
大学耳鼻喉科门诊。
共有20例嗅觉丧失患者参与本研究。嗅觉减退的持续时间为3个月至6年。
通过苯乙醇气味阈值、气味辨别和气味识别来评估嗅觉功能。使用磁共振成像确定嗅球体积。
在最初嗅觉减退的患者（n = 13）中，发现嗅球体积的变化与气味阈值变化相关（r = 0.82；P = .001）；在气味辨别或气味识别方面未发现此类相关性。
据我们所知，这是首次在纵向研究中证明，人类嗅球是一种高度可塑性的结构，对嗅觉状态的个体变化有反应。
