1,1'-羰基二咪唑促进丙二酸衍生物的温和脱羧活化。
Mild decarboxylative activation of malonic acid derivatives by 1,1'-carbonyldiimidazole.
机构信息
Development Science and Technology, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States.
出版信息
Org Lett. 2011 May 6;13(9):2322-5. doi: 10.1021/ol200575c. Epub 2011 Apr 13.
PMID:21488674
Abstract
Malonic acid derivatives undergo unusually mild decarboxylation when treated with N,N'-carbonyldiimidazole (CDI) at room temperature to generate the carbonyl imidazole moiety in high yield, which can be reacted further with a variety of nucleophiles in an efficient one-pot process.
摘要
丙二酸衍生物与 N,N'-羰基二咪唑（CDI）在室温下反应时会发生异常温和的脱羧反应，以高产率生成羰基咪唑部分，该部分可在一锅法中进一步与各种亲核试剂反应。
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