Dairy Science Department, Faculty of Agriculture, Cairo University, Egypt.
Lipids Health Dis. 2011 Apr 13;10:57. doi: 10.1186/1476-511X-10-57.
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and can vary from hepatic steatosis to end-stage liver disease. It is the most common liver disease and its prevalence is increasing worldwide. In the present study, the effect of whey proteins on some parameters of NAFLD was investigated.
Oral administration of the studied whey proteins products reduced the final body weight of rats. There was a significant reduction effect (P<0.05) of the tested proteins on hepatic triglycerides, liver enzymes (ALT and AST), lipid peroxidation (malondialdehyde level) and serum glucose. Feeding on whey proteins caused an increase in the reduced glutathione. Hepatic content of reduced glutathione was not affected by any of the used whey proteins, but it showed an increasing tendency (P>0.05). Liver histology showed an improvement of fatty infiltration in hepatocytes from whey protein groups and gives the histology of liver a normal appearance.
The obtained results indicate a possible role for oral administration of whey proteins in the regulation of liver biochemistries in a rat's model of NAFLD. This regulatory effect of whey proteins was accompanied by an improvement in fatty infiltration in hepatocytes and a reduction of oxidative stress parameters.
非酒精性脂肪性肝病（NAFLD）是代谢综合征的肝脏表现，可从单纯性肝脂肪变性发展为终末期肝病。它是最常见的肝脏疾病，其患病率在全球范围内呈上升趋势。本研究探讨了乳清蛋白对 NAFLD 某些参数的影响。
口服研究中的乳清蛋白产品可降低大鼠的最终体重。测试蛋白对肝甘油三酯、肝酶（ALT 和 AST）、脂质过氧化（丙二醛水平）和血清葡萄糖有显著降低作用（P<0.05）。乳清蛋白喂养可增加还原型谷胱甘肽。还原型谷胱甘肽在肝中的含量不受任何使用的乳清蛋白的影响，但有增加的趋势（P>0.05）。肝组织学显示乳清蛋白组肝细胞脂肪浸润得到改善，使肝脏组织学呈现正常外观。
这些结果表明，口服乳清蛋白可能在调节 NAFLD 大鼠模型的肝脏生化方面发挥作用。乳清蛋白的这种调节作用伴随着肝细胞脂肪浸润的改善和氧化应激参数的降低。
