脑脊液 tau 标志物与阿尔茨海默病患者的海马体积相关。

CSF tau markers are correlated with hippocampal volume in Alzheimer's disease.

机构信息

Université Pierre et Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de Moelle Épinière, UMR-S975, Paris, France.

出版信息

Neurobiol Aging. 2012 Jul;33(7):1253-7. doi: 10.1016/j.neurobiolaging.2011.02.022. Epub 2011 Apr 13.

DOI:10.1016/j.neurobiolaging.2011.02.022

PMID:21489655

Abstract

Hippocampal atrophy as assessed by magnetic resonance imaging (MRI) and abnormal cerebrospinal fluid (CSF) biomarkers are supportive features for the diagnosis of Alzheimer's disease (AD) and are assumed to be indirect pathological markers of the disease. In AD patients, antemortem MRI hippocampal volumes (HVs) correlate with the density of neurofibrillary tangles (but not with senile plaques) at autopsy suggesting that HVs may better correlate with CSF tau and hyperphosphorylated tau (P-tau) levels than CSF amyloid beta protein (Aβ)(42) level. Here, we tested this hypothesis in a well-defined AD group. Patients were selected according to the New Research Criteria for AD, including specific episodic memory deficit and CSF AD profile (defined as abnormal ratio of Aβ(42):tau). MRI was performed within 6 months of lumbar puncture. HVs were obtained using automated segmentation software. Thirty-six patients were included. Left HV correlated with CSF tau (R = -0.53) and P-tau (R = -0.56) levels. Mean HVs correlated with the CSF P-tau level (R = -0.52). No correlation was found between any brain measurement and CSF Aβ(42) level. The CSF tau and P-tau levels, but not the CSF Aβ(42) level, correlated with HV, suggesting that CSF tau markers reflect the neuronal loss associated with the physiopathological process of AD.

摘要

海马萎缩通过磁共振成像（MRI）和异常脑脊液（CSF）生物标志物评估，是阿尔茨海默病（AD）诊断的支持特征，被认为是疾病的间接病理标志物。在 AD 患者中，生前 MRI 海马体积（HV）与尸检时神经纤维缠结的密度相关（但与老年斑无关），这表明 HV 可能与 CSF tau 和过度磷酸化 tau（P-tau）水平比 CSF 淀粉样蛋白 beta 蛋白（Aβ）（42）水平更好地相关。在这里，我们在一个明确的 AD 组中测试了这一假设。根据 AD 的新研究标准选择患者，包括特定的情景记忆缺陷和 CSF AD 特征（定义为 Aβ（42）：tau 的异常比值）。MRI 在腰椎穿刺后 6 个月内进行。使用自动分割软件获得 HV。共纳入 36 例患者。左 HV 与 CSF tau（R = -0.53）和 P-tau（R = -0.56）水平相关。平均 HV 与 CSF P-tau 水平相关（R = -0.52）。任何脑测量值与 CSF Aβ（42）水平均无相关性。CSF tau 和 P-tau 水平，而不是 CSF Aβ（42）水平，与 HV 相关，表明 CSF tau 标志物反映了与 AD 生理病理过程相关的神经元丢失。