Pasqualini J R, Cornier E, Grenier J, Vella C, Schatz B, Netter A
CNRS, URA-548, Paris, France.
Pathol Biol (Paris). 1990 Nov;38(9):941-3.
Concentrations of estrogen receptors, progesterone receptors, unconjugated estrogens (estradiol and estrone) and sulfate-conjugated estrogens (estradiol sulfate and estrone sulfate) were determined in patients treated with Decapeptyl and in controls. After prolonged Decapeptyl therapy, a highly significant fall in progesterone receptors was evidenced; estrogen receptors were found to be decreased in the myoma as compared with the secretory phase in controls and in the myometrium as compared with the proliferative phase in controls. Tissue levels of estrone sulfate and estradiol sulfate decreased very substantially. In conclusion, Decapeptyl emerges as a very promising agent for the treatment of uterine myomas.
在接受曲普瑞林治疗的患者及对照组中测定了雌激素受体、孕激素受体、未结合雌激素（雌二醇和雌酮）以及硫酸酯结合雌激素（硫酸雌二醇和硫酸雌酮）的浓度。经过长期曲普瑞林治疗后，证实孕激素受体显著下降；与对照组分泌期相比，肌瘤中的雌激素受体减少，与对照组增殖期相比，子宫肌层中的雌激素受体减少。硫酸雌酮和硫酸雌二醇的组织水平大幅下降。总之，曲普瑞林成为治疗子宫肌瘤的一种非常有前景的药物。
