Pasqualini J R, Cornier E, Grenier J, Vella C, Schatz B, Netter A
C.N.R.S. Steroid Hormone Research Unit, Foundation for Hormone Research, Paris, France.
Fertil Steril. 1990 Jun;53(6):1012-7.
Estrogens (estrone [E1] and estradiol [E2]), their sulfates and progesterone receptor (PR) were evaluated in patients with uterine leiomyomata nontreated and treated with Decapeptyl (D-Trp6-gonadotropin-releasing hormone [GnRH]; Ipsen Biotech, Paris, France). Estrogen concentrations are very high in the leiomyoma (secretory phase, pg/g tissue [mean +/- SEM]: n = 10; E1: 147 +/- 24; E2: 850 +/- 116; E1-sulfate: 1,668 +/- 808; E2-sulfate: 718 +/- 126). Decapeptyl treatment provokes a significant decrease in E2 and particularly in E1 and E2 sulfates. Progesterone receptors were higher in the leiomyoma than in the myometrium; after a long treatment (3 to 4 months) a significant decrease in both tissues is observed. The decrease provoked by D-Trp6-GnRH on estrogens (unconjugated and sulfates) and in PR in the leiomyoma after long treatment, supports the hypothesis that estrogens are implicated in the cause of these tumors.
对未接受治疗及接受曲普瑞林（D-色氨酸6-促性腺激素释放激素[GnRH]；法国巴黎益普生生物技术公司生产）治疗的子宫肌瘤患者的雌激素（雌酮[E1]和雌二醇[E2]）、其硫酸盐及孕激素受体（PR）进行了评估。子宫肌瘤中的雌激素浓度非常高（分泌期，pg/g组织[均值±标准误]：n = 10；E1：147±24；E2：850±116；E1-硫酸盐：1,668±808；E2-硫酸盐：718±126）。曲普瑞林治疗可使E2，尤其是E1和E2硫酸盐显著降低。子宫肌瘤中的孕激素受体高于子宫肌层；经过长期治疗（3至4个月）后，观察到两种组织中的孕激素受体均显著降低。长期治疗后，D-色氨酸6-GnRH对子宫肌瘤中雌激素（未结合型和硫酸盐型）及PR的降低作用支持了雌激素与这些肿瘤病因有关的假说。
