Tsao P S, Lefer A M
Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Res Commun Chem Pathol Pharmacol. 1990 Nov;70(2):205-11.
We studied the effects of a novel thromboxane receptor antagonist (+)-S145Na, on the loss of myocardial creatine kinase activity in the rat myocardium after 10 minutes of coronary artery ligation, followed by 24 hours of reperfusion. (+)-S145Na (500 micrograms/kg), or its vehicle, was administered 10 minutes after occlusion (just prior to reperfusion) intravenously. Myocardial creatine kinase activity was significantly reduced in the ischemic areas of hearts obtained from rats receiving vehicle when compared to sham operated control rats. This loss in creatine kinase activity was significantly attenuated in hearts obtained from rats receiving (+)-S145Na. These findings further support the important role of thromboxane A2 in the pathogenesis of reperfusion injury following myocardial ischemia, and that (+)-S145Na may be a useful agent in the treatment of myocardial reperfusion injury.
我们研究了新型血栓素受体拮抗剂（+）-S145Na对大鼠冠状动脉结扎10分钟后再灌注24小时心肌肌酸激酶活性丧失的影响。在闭塞后10分钟（即将再灌注前）静脉注射（+）-S145Na（500微克/千克）或其溶媒。与假手术对照大鼠相比，接受溶媒的大鼠心脏缺血区域的心肌肌酸激酶活性显著降低。在接受（+）-S145Na的大鼠心脏中，肌酸激酶活性的这种丧失显著减轻。这些发现进一步支持了血栓素A2在心肌缺血后再灌注损伤发病机制中的重要作用，以及（+）-S145Na可能是治疗心肌再灌注损伤的有用药物。
