Center for Platelet Research Studies, Children's Hospital Boston, Karp 08213, 300 Longwood Avenue, Boston, Massachusetts 02115-5737, USA.
Nat Rev Drug Discov. 2010 Feb;9(2):154-69. doi: 10.1038/nrd2957.
Antiplatelet therapy has been successful in reducing mortality and morbidity in acute myocardial infarction. Recent advances in understanding the molecular basis of the role of platelets in cardiovascular thrombosis have enabled the development of new agents with the potential to further reduce mortality and morbidity. This article reviews the role of platelets in haemostasis and cardiovascular thrombosis, and discusses the benefits and limitations of current and investigational antiplatelet agents in the treatment of cardiovascular disease.
抗血小板治疗已成功降低急性心肌梗死的死亡率和发病率。对血小板在心血管血栓形成中作用的分子基础的深入了解，使具有进一步降低死亡率和发病率潜力的新型药物得以开发。本文综述了血小板在止血和心血管血栓形成中的作用，并讨论了目前和正在研究的抗血小板药物在心血管疾病治疗中的益处和局限性。
