乙型肝炎病毒所致肝病及免疫接种后针对前S1的抗体反应。

Antibody response to preS1 in hepatitis-B-virus-induced liver disease and after immunization.

作者信息

Coursaget P, Buisson Y, Bourdil C, Yvonnet B, Molinié C, Diop M T, Chiron J P, Bao O, Diop-Mar I

机构信息

Institut de Virologie de Tours et Laboratoire de Microbiologie, Faculté de Pharmacie, France.

出版信息

Res Virol. 1990 Sep-Oct;141(5):563-70. doi: 10.1016/0923-2516(90)90087-y.

DOI:10.1016/0923-2516(90)90087-y

PMID:2148981

Abstract

Antibodies to the pre-S1-encoded sequence of hepatitis B virus (HBV) envelope were detected by ELISA using a synthetic peptide analogue of preS1 proteins, in different groups of HBV-infected subjects and also in hepatitis B vaccine recipients. Such antibodies were specifically found in only 1% of HBsAg chronic carriers including patients with cirrhosis and primary liver cancer. Anti-preS1 were detected in patients with acute hepatitis; in 13% of the HBsAg+ sera obtained before recovery and in 37% of the sera obtained after recovery. Anti-preS1 antibodies were detected in recipients of a plasma-derived vaccine, but not in those receiving a recombinant vaccine. The results indicate that anti-preS1 is an earlier serum marker of HBV clearance than anti-preS2 and anti-S antibodies.

摘要

采用前S1蛋白的合成肽类似物，通过酶联免疫吸附测定法（ELISA）在不同组的乙肝病毒（HBV）感染受试者以及乙肝疫苗接种者中检测了针对乙肝病毒包膜前S1编码序列的抗体。此类抗体仅在1%的HBsAg慢性携带者（包括肝硬化和原发性肝癌患者）中被特异性检测到。在急性肝炎患者中检测到了抗前S1抗体；在恢复前获得的HBsAg阳性血清中有13%检测到该抗体，恢复后获得的血清中有37%检测到该抗体。在接受血浆源性疫苗的接种者中检测到了抗前S1抗体，但在接受重组疫苗的接种者中未检测到。结果表明，抗前S1抗体是比抗前S2和抗S抗体更早出现的乙肝病毒清除血清标志物。