X 连锁 FoxP3 基因在人类癌症中的双重作用。
The dual role of the X-linked FoxP3 gene in human cancers.
机构信息
Department of Pathology, McGill University, Montreal, QC, Canada.
出版信息
Mol Oncol. 2011 Apr;5(2):156-63. doi: 10.1016/j.molonc.2011.03.001. Epub 2011 Mar 30.
Abstract
The FoxP3 (forkhead box P3) gene is an X-linked gene that is submitted to inactivation. It is an essential transcription factor in CD4(+)CD25(+)FoxP3 regulatory T cells, which are therapeutic targets in disseminated cutaneous melanoma. Moreover, FoxP3 is an important tumor suppressor gene in carcinomas and has putative cancer suppressor gene function in cutaneous melanoma as well. Therefore understanding the structure and function of the FoxP3 gene is crucial to gaining insight into the biology of melanoma to better develop immunotherapeutics and future therapeutic strategies.
摘要
叉头框蛋白 P3（FoxP3）基因是一个位于 X 染色体上的基因，会发生失活。它是 CD4(+)CD25(+)FoxP3 调节性 T 细胞中的一个必需转录因子，而调节性 T 细胞是播散性皮肤黑色素瘤的治疗靶点。此外，FoxP3 是癌中的一个重要肿瘤抑制基因，在皮肤黑色素瘤中也具有潜在的肿瘤抑制基因功能。因此，了解 FoxP3 基因的结构和功能对于深入了解黑色素瘤的生物学特性、更好地开发免疫疗法和未来的治疗策略至关重要。
相似文献
1
The dual role of the X-linked FoxP3 gene in human cancers.X 连锁 FoxP3 基因在人类癌症中的双重作用。
Mol Oncol. 2011 Apr;5(2):156-63. doi: 10.1016/j.molonc.2011.03.001. Epub 2011 Mar 30.
2
The Role of FOXP3 in Human Cancers.FOXP3在人类癌症中的作用。
Anticancer Res. 2016 Aug;36(8):3789-94.
3
FOXP3+CD25- tumor cells with regulatory function in Sézary syndrome.在蕈样肉芽肿中具有调节功能的FOXP3 + CD25 - 肿瘤细胞。
J Invest Dermatol. 2009 Dec;129(12):2875-85. doi: 10.1038/jid.2009.175. Epub 2009 Jul 23.
4
Signalling through FOXP3 as an X-linked tumor suppressor.FOXP3 通过信号通路作为 X 连锁的肿瘤抑制因子。
Int J Biochem Cell Biol. 2010 Nov;42(11):1784-7. doi: 10.1016/j.biocel.2010.07.015. Epub 2010 Aug 1.
5
The vast majority of lymphocytes infiltrating primary cutaneous melanoma express the CD27 costimulatory receptor: implications for melanoma progression.绝大多数浸润原发性皮肤黑素瘤的淋巴细胞表达 CD27 共刺激受体：对黑素瘤进展的影响。
Eur J Dermatol. 2011 Mar-Apr;21(2):178-83. doi: 10.1684/ejd.2010.1240.
6
[Inhibitory effect of lentiviral-mediated RNA on the expression of Foxp3 protein in melanoma cells].[慢病毒介导的RNA对黑色素瘤细胞中Foxp3蛋白表达的抑制作用]
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Apr;28(4):337-9.
7
FOXP3 is not mutated in human melanoma.FOXP3在人类黑色素瘤中未发生突变。
Pigment Cell Melanoma Res. 2012 May;25(3):398-400. doi: 10.1111/j.1755-148X.2012.00993.x. Epub 2012 Mar 16.
8
Immunoregulatory T cells in the peripheral blood of melanoma patients treated with melanoma antigen-pulsed mature monocyte-derived dendritic cell vaccination.接受黑色素瘤抗原脉冲成熟单核细胞来源树突状细胞疫苗治疗的黑色素瘤患者外周血中的免疫调节性T细胞
J Dermatol Sci. 2009 Apr;54(1):31-7. doi: 10.1016/j.jdermsci.2008.11.007. Epub 2009 Jan 20.
9
Role of STAT3 in CD4+CD25+FOXP3+ regulatory lymphocyte generation: implications in graft-versus-host disease and antitumor immunity.信号转导与转录激活因子3（STAT3）在CD4+CD25+FOXP3+调节性淋巴细胞生成中的作用：对移植物抗宿主病和抗肿瘤免疫的影响
J Immunol. 2007 Dec 1;179(11):7593-604. doi: 10.4049/jimmunol.179.11.7593.
10
Foxp3 expression in CD4CD25Foxp3 regulatory T cells promotes development of colorectal cancer by inhibiting tumor immunity.CD4CD25Foxp3调节性T细胞中Foxp3的表达通过抑制肿瘤免疫促进结直肠癌的发展。
J Huazhong Univ Sci Technolog Med Sci. 2016 Oct;36(5):677-682. doi: 10.1007/s11596-016-1644-1. Epub 2016 Oct 18.
引用本文的文献
1
FoxP3 expression by retinal pigment epithelial cells: transcription factor with potential relevance for the pathology of age-related macular degeneration.视网膜色素上皮细胞中的 FoxP3 表达：转录因子与年龄相关性黄斑变性的病理学可能相关。
J Neuroinflammation. 2022 Oct 22;19(1):260. doi: 10.1186/s12974-022-02620-w.
2
Epigenetic Alteration and its Association With Downregulated FOXP3 Gene in Indian Breast Cancer Patients.印度乳腺癌患者的表观遗传改变及其与FOXP3基因下调的关联。
Front Genet. 2021 Nov 29;12:781400. doi: 10.3389/fgene.2021.781400. eCollection 2021.
3
Peritoneal Modulators of Endometriosis-Associated Ovarian Cancer.子宫内膜异位症相关卵巢癌的腹膜调节因子
Front Oncol. 2021 Nov 25;11:793297. doi: 10.3389/fonc.2021.793297. eCollection 2021.
4
Forkhead Box Protein P3 (FOXP3) Represses ATF3 Transcriptional Activity.叉头框蛋白 P3（FOXP3）抑制 ATF3 的转录活性。
Int J Mol Sci. 2021 Oct 22;22(21):11400. doi: 10.3390/ijms222111400.
5
FoxP3-miR-150-5p/3p suppresses ovarian tumorigenesis via an IGF1R/IRS1 pathway feedback loop.FoxP3-miR-150-5p/3p 通过 IGF1R/IRS1 通路反馈环抑制卵巢肿瘤发生。
Cell Death Dis. 2021 Mar 15;12(3):275. doi: 10.1038/s41419-021-03554-6.
6
FOXP3 in Melanoma with Regression: Between Tumoral Expression and Regulatory T Cell Upregulation.FOXP3 在消退型黑素瘤中的表达：肿瘤表达与调节性 T 细胞上调之间的关系。
J Immunol Res. 2020 Oct 23;2020:5416843. doi: 10.1155/2020/5416843. eCollection 2020.
7
The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis.叉头框转录因子家族：结直肠癌发病机制中的关键分子。
Mol Cancer. 2019 Jan 8;18(1):5. doi: 10.1186/s12943-019-0938-x.
8
FOXP3 Activates SUMO-Conjugating Gene in MCF7 Breast Cancer Cells.FOXP3 在 MCF7 乳腺癌细胞中激活 SUMO 连接酶基因。
Int J Mol Sci. 2018 Jul 13;19(7):2036. doi: 10.3390/ijms19072036.
9
CD44 induces FOXP3 expression and is related with favorable outcome in breast carcinoma.CD44可诱导FOXP3表达，且与乳腺癌的良好预后相关。
Virchows Arch. 2017 Jan;470(1):81-90. doi: 10.1007/s00428-016-2045-3. Epub 2016 Nov 24.
10
Overexpression of the transcription factor FOXP3 in lung adenocarcinoma sustains malignant character by promoting G1/S transition gene CCND1.转录因子FOXP3在肺腺癌中的过表达通过促进G1/S转换基因CCND1来维持恶性特征。
Tumour Biol. 2016 Jun;37(6):7395-404. doi: 10.1007/s13277-015-4616-3. Epub 2015 Dec 16.
本文引用的文献
1
Human FoxP3(+)CD4(+) regulatory T cells: their knowns and unknowns.人源 FoxP3(+)CD4(+) 调节性 T 细胞：已知与未知。
Immunol Cell Biol. 2011 Mar;89(3):346-51. doi: 10.1038/icb.2010.137. Epub 2011 Feb 8.
2
Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers.在乳腺癌和前列腺癌中鉴定 FOXP3 和 Hippo 通路之间的肿瘤抑制因子 relay。
Cancer Res. 2011 Mar 15;71(6):2162-71. doi: 10.1158/0008-5472.CAN-10-3268. Epub 2011 Jan 28.
3
CD28 costimulation regulates FOXP3 in a RelA/NF-κB-dependent mechanism.CD28 共刺激通过 RelA/NF-κB 依赖的机制调节 FOXP3。
Eur J Immunol. 2011 Feb;41(2):503-13. doi: 10.1002/eji.201040712. Epub 2011 Jan 11.
4
Distinct inflammatory signals have physiologically divergent effects on epigenetic regulation of Foxp3 expression and Treg function.不同的炎症信号对 Foxp3 表达和 Treg 功能的表观遗传调控具有生理上的差异。
Am J Transplant. 2011 Feb;11(2):203-14. doi: 10.1111/j.1600-6143.2010.03389.x. Epub 2011 Jan 10.
5
Reviewing once more the c-myc and Ras collaboration: converging at the cyclin D1-CDK4 complex and challenging basic concepts of cancer biology.再次回顾 c-myc 和 Ras 的合作：在细胞周期蛋白 D1-CDK4 复合物汇聚并挑战癌症生物学的基本概念。
Cell Cycle. 2011 Jan 1;10(1):57-67. doi: 10.4161/cc.10.1.14449.
6
Perturbations of both nonregulatory and regulatory FOXP3+ T cells in patients with malignant melanoma.恶性黑色素瘤患者中非调节性和调节性 FOXP3+ T 细胞的紊乱。
Br J Dermatol. 2011 May;164(5):1052-60. doi: 10.1111/j.1365-2133.2010.10199.x. Epub 2011 Apr 5.
7
Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases.人类自身免疫性疾病中 CD4(+)CD25(+)FOXP3(+)调节性 T 细胞功能障碍的调节机制。
Nat Rev Immunol. 2010 Dec;10(12):849-59. doi: 10.1038/nri2889.
8
The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells.体内过度的 IL-6 产生对 Foxp3+ 调节性 T 细胞的发育和功能的影响。
J Immunol. 2011 Jan 1;186(1):32-40. doi: 10.4049/jimmunol.0903314. Epub 2010 Nov 24.
9
Association of single-nucleotide polymorphisms in FOXP3 gene with systemic lupus erythematosus susceptibility: a case-control study.FOXP3 基因单核苷酸多态性与系统性红斑狼疮易感性的关联：一项病例对照研究。
Lupus. 2011 Feb;20(2):137-43. doi: 10.1177/0961203310382428. Epub 2010 Nov 15.
10
FOXP3 as an X-linked tumor suppressor.叉头框蛋白P3作为一种X连锁肿瘤抑制因子。
Discov Med. 2010 Oct;10(53):322-8.
Zotero 插件