Department of Pathology, McGill University, Montreal, QC, Canada.
Mol Oncol. 2011 Apr;5(2):156-63. doi: 10.1016/j.molonc.2011.03.001. Epub 2011 Mar 30.
The FoxP3 (forkhead box P3) gene is an X-linked gene that is submitted to inactivation. It is an essential transcription factor in CD4(+)CD25(+)FoxP3 regulatory T cells, which are therapeutic targets in disseminated cutaneous melanoma. Moreover, FoxP3 is an important tumor suppressor gene in carcinomas and has putative cancer suppressor gene function in cutaneous melanoma as well. Therefore understanding the structure and function of the FoxP3 gene is crucial to gaining insight into the biology of melanoma to better develop immunotherapeutics and future therapeutic strategies.
叉头框蛋白 P3（FoxP3）基因是一个位于 X 染色体上的基因，会发生失活。它是 CD4(+)CD25(+)FoxP3 调节性 T 细胞中的一个必需转录因子，而调节性 T 细胞是播散性皮肤黑色素瘤的治疗靶点。此外，FoxP3 是癌中的一个重要肿瘤抑制基因，在皮肤黑色素瘤中也具有潜在的肿瘤抑制基因功能。因此，了解 FoxP3 基因的结构和功能对于深入了解黑色素瘤的生物学特性、更好地开发免疫疗法和未来的治疗策略至关重要。
