Department of Dermatology, Firat University Faculty of Medicine, TR23119, Elazig, Turkey.
Eur J Dermatol. 2011 Mar-Apr;21(2):203-8. doi: 10.1684/ejd.2011.1252.
Behcet's disease (BD) is a chronic and recurrent systemic vasculitis marked by macrophage chemotaxis.
The present study aimed to examine the relationship between the osteopontin molecule and BD.
The study registered 60 patients with BD, as well as 50 healthy individuals and 63 patients with psoriasis as the control group. Patients with BD in our study were divided into 2 groups, with regard to mucocutaneous involvement, as active and inactive patients. In addition, patients with BD were also divided into 3 groups with regard to vascular involvement: active, inactive, and no vascular involvement.
Plasma osteopontin (OPN) levels in active patients with BD, inactive patients with BD and patients with psoriasis were found statistically significantly elevated, in comparison to those in the healthy control group (p < 0.001, p = 0.008, p < 0.001, respectively). When active and inactive patients with BD were compared to the healthy control group with regard to vascular involvement, mean plasma OPN levels were found to be statistically significantly higher (p = 0.01, p < 0.001, respectively).
We found that plasma levels of OPN were higher in patients with Behcet's and psoriasis.
白塞病（BD）是一种慢性复发性系统性血管炎，其特征是巨噬细胞趋化作用。
本研究旨在探讨骨桥蛋白分子与 BD 的关系。
本研究登记了 60 例 BD 患者、50 名健康对照者和 63 例银屑病患者作为对照组。我们研究中的 BD 患者分为两组，即黏膜皮肤受累的活动期和非活动期患者。此外，BD 患者还根据血管受累情况分为三组：活动期、非活动期和无血管受累。
BD 活动期患者、BD 非活动期患者和银屑病患者的血浆骨桥蛋白（OPN）水平明显高于健康对照组（p<0.001、p=0.008、p<0.001）。当比较有血管受累的活动期和非活动期 BD 患者与健康对照组时，发现平均血浆 OPN 水平明显更高（p=0.01、p<0.001）。
我们发现，BD 和银屑病患者的血浆 OPN 水平较高。
