UCSD Department of Ophthalmology, Shiley Eye Center, La Jolla, CA, USA.
Ophthalmic Plast Reconstr Surg. 2011 Sep-Oct;27(5):348-51. doi: 10.1097/IOP.0b013e3182141c37.
Few studies have focused on the aging changes in the upper eyelid. This study evaluated the differential changes in the nasal and central fat pads of the upper eyelid associated with aging.
In this retrospective, consecutive series, the medical records and photographs of 77 patients were reviewed. The patients were grouped in 7 categories according to decade of life. Using a standardized scale, the volume grade of the nasal and central fat pads was graded from 0 to 3. Statistical evaluation correlating age with central and nasal fat pad change was performed.
With aging, the central fat pad volume appeared to diminish, with relative sparing of the nasal fat pad. There was a positive correlation of the volume grade of the nasal fat pad with age and a negative correlation of the central fat pad with age. In addition, there was a statistically significant difference between the volume grades of the nasal and central fat pads in the groups 70 years and older.
With aging, there appears to be a pattern of differential fat pad alteration. This study shows that in the upper eyelids of patients >70 years of age, the medial fat pad becomes prominent whereas the central fat pad atrophies. Teleologically, the relative preservation of nasal fat may be due to its higher abundance of neural-crest progenitor cells. Clinically, this finding has implications in esthetic and functional upper eyelid blepharoplasty.
很少有研究关注上眼睑的老化变化。本研究评估了与衰老相关的上眼睑鼻侧和中央脂肪垫的差异变化。
在这项回顾性连续系列研究中，回顾了 77 例患者的病历和照片。患者根据生活的十年分为 7 组。使用标准化量表，将鼻侧和中央脂肪垫的体积等级从 0 到 3 分级。对年龄与中央和鼻侧脂肪垫变化的相关性进行统计学评估。
随着年龄的增长，中央脂肪垫体积似乎减少，而鼻侧脂肪垫相对保留。鼻侧脂肪垫的体积等级与年龄呈正相关，中央脂肪垫与年龄呈负相关。此外，在 70 岁及以上的组中，鼻侧和中央脂肪垫的体积等级之间存在统计学显著差异。
随着年龄的增长，似乎存在脂肪垫差异改变的模式。本研究表明，在 >70 岁的患者的上眼睑中，内侧脂肪垫变得突出，而中央脂肪垫萎缩。从目的论的角度来看，鼻侧脂肪的相对保留可能是由于其含有更多的神经嵴祖细胞。临床上，这一发现对上眼睑美容和功能性眼睑成形术具有重要意义。
