可溶性腺苷酸环化酶介导的细胞内 cAMP 信号转导。
Intracellular cAMP signaling by soluble adenylyl cyclase.
机构信息
Marine Biology Research Division, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.
出版信息
Kidney Int. 2011 Jun;79(12):1277-88. doi: 10.1038/ki.2011.95. Epub 2011 Apr 13.
Abstract
Soluble adenylyl cyclase (sAC) is a recently identified source of the ubiquitous second messenger cyclic adenosine 3',5' monophosphate (cAMP). sAC is distinct from the more widely studied source of cAMP, the transmembrane adenylyl cyclases (tmACs); its activity is uniquely regulated by bicarbonate anions, and it is distributed throughout the cytoplasm and in cellular organelles. Due to its unique localization and regulation, sAC has various functions in a variety of physiological systems that are distinct from tmACs. In this review, we detail the known functions of sAC, and we reassess commonly held views of cAMP signaling inside cells.
摘要
可溶性腺苷酸环化酶（sAC）是一种最近被发现的普遍存在的第二信使环磷酸腺苷（cAMP）的来源。sAC 与更广泛研究的 cAMP 来源——跨膜腺苷酸环化酶（tmACs）不同；其活性被独特地调节，由碳酸氢盐阴离子调节，并且分布在细胞质和细胞细胞器中。由于其独特的定位和调节，sAC 在各种生理系统中具有与 tmACs 不同的各种功能。在这篇综述中，我们详细介绍了 sAC 的已知功能，并重新评估了细胞内 cAMP 信号传递的普遍观点。
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